Huq N, Akond A K, Kabir E
Department of Pathology, Dhaka Medical College, Dhaka, Bangladesh.
Mymensingh Med J. 2010 Jan;19(1):89-93.
Nephrotic syndrome in children is a clinical manifestation of different histopathological subtypes of glomerulopathies. There is a paucity of studies about the histopathological spectrum of childhood nephrotic syndrome in our country. A cross sectional study was carried out from July 2005 to June 2007 with the aim to see the pattern of glomerulonephritis in renal biopsy samples of childhood nephrotic syndrome along with types of immune deposition. Thirty paediatric patients with their relevant clinical history and renal biopsy were evaluated by light microscopic study and by immunofluorescence microscopy. Mesangial-proliferative glomerulonephritis was found to be the most common cause of nephrotic syndrome followed by minimal change disease in the present study. IgM was found to be the most frequent form of immune deposition in case of mesangial proliferative glomerulonephritis.
儿童肾病综合征是肾小球病不同组织病理学亚型的一种临床表现。我国关于儿童肾病综合征组织病理学谱的研究较少。2005年7月至2007年6月进行了一项横断面研究，目的是观察儿童肾病综合征肾活检样本中肾小球肾炎的模式以及免疫沉积类型。通过光学显微镜研究和免疫荧光显微镜对30例有相关临床病史和肾活检的儿科患者进行了评估。在本研究中，系膜增生性肾小球肾炎被发现是肾病综合征最常见的病因，其次是微小病变病。在系膜增生性肾小球肾炎病例中，IgM被发现是最常见的免疫沉积形式。
