没有证据表明酪氨酸羟化酶基因 Val81Met 多态性与精神分裂症迟发性运动障碍易感性有关。
No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia.
机构信息
Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
出版信息
Psychiatry Investig. 2009 Jun;6(2):108-11. doi: 10.4306/pi.2009.6.2.108. Epub 2009 Jun 30.
OBJECTIVE
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a candidate marker for susceptibility to dopamine-related traits. We investigated the hypothesis that TH Val81Met polymorphism can influence susceptibility to tardive dyskinesia (TD) in schizophrenia.
METHODS
TH Val81Met polymorphism was analyzed by PCR-based methods in 83 schizophrenic patients with TD and 126 schizophrenic patients without TD, matched for antipsychotic drug exposure and other relevant variables.
RESULTS
There was no significant association of the genotype and allele frequencies determined by the TH Val81Met polymorphism between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups.
CONCLUSION
Within the limitations imposed by the size of the clinical sample, these findings suggest that the Val81Met polymorphism of the TH gene does not contribute significantly to the risk for TD.
目的
酪氨酸羟化酶（TH）是多巴胺生物合成的限速酶。由于 TH Val81Met 多态性位于四聚体酶的氨基末端调节结构域，因此它是多巴胺相关特征易感性的候选标志物。我们研究了 TH Val81Met 多态性是否会影响精神分裂症迟发性运动障碍（TD）易感性的假设。
方法
通过基于 PCR 的方法分析了 83 例伴有 TD 的精神分裂症患者和 126 例无 TD 的精神分裂症患者的 TH Val81Met 多态性，这些患者在抗精神病药物暴露和其他相关变量方面相匹配。
结果
TD 与非 TD 患者的 TH Val81Met 多态性确定的基因型和等位基因频率之间没有显著关联。此外，三组基因型之间的总异常不自主运动量表评分没有差异。
结论
在临床样本大小的限制内，这些发现表明 TH 基因的 Val81Met 多态性对 TD 的风险没有显著贡献。
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