Kang Seung-Gul, Choi Jung-Eun, Park Young-Min, Lee Heon-Jeong, Han Changsu, Kim Yong-Ku, Kim Seung-Hyun, Lee Min-Soo, Joe Sook-Haeng, Jung In-Kwa, Kim Leen
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea.
Neuropsychobiology. 2008;57(1-2):22-5. doi: 10.1159/000123118. Epub 2008 Apr 18.
This study investigated whether the catechol-O-methyltransferase (COMT) gene V158M single-nucleotide polymorphism (SNP) influences susceptibility to tardive dyskinesia (TD).
We examined 209 Korean schizophrenic patients using the Abnormal Involuntary Movement Scale (AIMS), with genotyping performed for the COMT gene V158M SNP.
The logistic regression analysis showed that old age [p = 0.032, OR = 1.40 (OR corresponds to 10-year), 95% CI = 1.03-1.90] was a risk factor for TD, but there was no significant association between the COMT genotype and TD. The heterozygotes (MV genotype) of the COMT gene polymorphism tended to develop TD less than homozygotes (MM and VV); however, the risk did not reach statistical significance (p = 0.050, OR = 1.81, 95% CI = 1.00-3.29).
These results suggest that the V158M SNP of the COMT gene is not associated with TD in schizophrenia. However, there is a tendency that the heterozygous genotype of the COMT gene polymorphism has a protective effect against TD. Further investigations are warranted to evaluate a molecular heterosis of this polymorphism in development of TD in a large sample of subjects.
本研究调查儿茶酚-O-甲基转移酶（COMT）基因V158M单核苷酸多态性（SNP）是否影响迟发性运动障碍（TD）的易感性。
我们使用异常不自主运动量表（AIMS）对209名韩国精神分裂症患者进行了检查，并对COMT基因V158M SNP进行基因分型。
逻辑回归分析显示，老年[p = 0.032，OR = 1.40（OR对应10年），95% CI = 1.03 - 1.90]是TD的一个危险因素，但COMT基因型与TD之间无显著关联。COMT基因多态性的杂合子（MV基因型）发生TD的倾向低于纯合子（MM和VV）；然而，风险未达到统计学显著性（p = 0.050，OR = 1.81，95% CI = 1.00 - 3.29）。
这些结果表明，COMT基因的V158M SNP与精神分裂症中的TD无关。然而，有这样一种倾向，即COMT基因多态性的杂合基因型对TD有保护作用。有必要进行进一步研究，以在大量受试者样本中评估这种多态性在TD发生过程中的分子杂种优势。
