在韩国人群中，色氨酸羟化酶 1 基因 A218C 多态性与精神分裂症的攻击性之间没有关联的证据。
No evidence of an association between A218C polymorphism of the tryptophan hydroxylase 1 gene and aggression in schizophrenia in a Korean population.
机构信息
Department of Neuropsychiatry, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
出版信息
Yonsei Med J. 2010 Jan;51(1):27-32. doi: 10.3349/ymj.2010.51.1.27. Epub 2009 Dec 29.
PURPOSE
We investigated the association between the tryptohan hydroxylase 1 (TPH1) gene and aggression in schizophrenia in a Korean population.
MATERIALS AND METHODS
The sample included 61 aggressive patients as well as 104 non-aggressive patients from psychiatric hospitals and 335 healthy volunteers in Korea. Blood samples were collected from all participants for TPH1 A218C genotyping. The patients were administered standard psychiatric interviews as well as a self-report questionnaire for anger-related traits.
RESULTS
In the case-control phenotypic comparisons, there was no significant association between the aggressive patients and the TPH1 A218C polymorphism. There was no significant effect of the TPH1 genotype on the anger-related traits, or no significant interaction between the genotype and group (aggressive and non-aggressive patients).
CONCLUSION
These findings suggest that TPH1 does not play a major role in aggressive behavior via anger in schizophrenic patients.
目的
我们在韩国人群中调查了色氨酸羟化酶 1（TPH1）基因与精神分裂症攻击行为之间的关系。
材料与方法
该样本包括来自精神病院的 61 名攻击性患者和 104 名非攻击性患者，以及 335 名韩国健康志愿者。所有参与者均采集血样进行 TPH1 A218C 基因分型。对患者进行标准精神病访谈以及与愤怒相关特质的自我报告问卷评估。
结果
在病例对照表型比较中，攻击性患者与 TPH1 A218C 多态性之间没有显著关联。TPH1 基因型对愤怒相关特质没有显著影响，或者基因型与组（攻击性和非攻击性患者）之间没有显著的相互作用。
结论
这些发现表明 TPH1 并非通过精神分裂症患者的愤怒在攻击行为中起主要作用。
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