Lee Hun, Yoon Jin Sook, Lee Sang Yeul
Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
Korean J Ophthalmol. 2009 Dec;23(4):235-9. doi: 10.3341/kjo.2009.23.4.235. Epub 2009 Dec 4.
To evaluate the safety and efficacy of fractional photothermolysis (FP) in the treatment of facial wrinkles in Asians.
A total of 27 Korean patients (Fitzpatrick type III or IV) received 2-3 FP treatment sessions (Sellas; Dinona Inc., Seoul, Korea) spaced two weeks apart. Treatments were performed at settings of 7 to 9 mJ/microthermal treatment zone (MTZ) and a density of 1000 MTZ/cm(2). Standardized digital photographs were obtained before each treatment and three months after the final treatment. The evaluations of clinical photographs were performed by three physicians blinded to the study subjects using a five-point grading scale. In addition, the patients' perceived degree of improvement was assessed three months after the final treatment using a five-point grading scale. Side effects were monitored at each follow-up visit.
The physicians' assessed degrees of improvement were excellent in three patients (12%), significant in ten (40%), and moderate in seven (28%). The patients' self-assessed degrees of improvement were excellent in five patients (20%), significant in 11 (44%), and moderate in six (24%). Adverse events were limited to transient pain, erythema and edema, except in one case of transient postinflammatory hyperpigmentation.
FP is an effective treatment modality for reducing facial wrinkles with minimal side effects in Asian patients.
评估分次光热解（FP）治疗亚洲人面部皱纹的安全性和有效性。
共有27名韩国患者（Fitzpatrick III型或IV型）接受了2 - 3次FP治疗（Sellas；Dinona公司，韩国首尔），每次治疗间隔两周。治疗参数设置为7至9 mJ/微热治疗区（MTZ），密度为1000 MTZ/cm²。在每次治疗前和最后一次治疗后三个月拍摄标准化数码照片。由三名对研究对象不知情的医生使用五点分级量表对临床照片进行评估。此外，在最后一次治疗后三个月使用五点分级量表评估患者自我感觉的改善程度。每次随访时监测副作用。
医生评估的改善程度为：3例（12%）优秀，10例（40%）显著，7例（28%）中等。患者自我评估的改善程度为：5例（20%）优秀，11例（44%）显著，6例（24%）中等。不良事件仅限于短暂疼痛、红斑和水肿，1例出现短暂的炎症后色素沉着过度。
FP是一种治疗亚洲患者面部皱纹有效的方法，副作用最小。
