Center for Modern Aesthetics & Laser Medicine am Aasee, aestheso, Münster, Germany.
J Dtsch Dermatol Ges. 2012 Dec;10(12):898-904. doi: 10.1111/j.1610-0387.2012.07986.x. Epub 2012 Jul 9.
Fractionated photothermolysis (FP) is used for the treatment of facial wrinkles.
Investigation of effects of different FP treatment parameters in the treatment of facial wrinkles.
In a randomized split-face controlled study 11 patients received 3 FP sessions in 4-week intervals. Keeping the total energy input for each facial side constant, one side was treated with 6 mJ/MTZ with relatively high MTZ density (up to 2,625 MTZ/cm(2) ) and the contralateral side with 70 mJ/MTZ with lower MTZ density (up to 230 MTZ/cm(2) ). Follow-up (FU) visits were performed 1, 3, and 6 months after the last treatment. The cosmetic evaluation was done by the patient self-assessments and by assessment of standardized photographs by 3 independent, blinded investigators. Post-treatment side effects were documented daily in a patient diary up to 7 days after the procedure.
After 6 months, the patient self-assessments indicated significant improvements (p < 0.005) in wrinkle severity from 5.2 ± 1.5 to 3.8 ± 1.3 and 3.7 ± 1.3 for 6 and 70 mJ/MTZ, respectively, but without significant difference between the energy levels. In contrast, the photographic evaluation by the blinded investigators showed that wrinkle severity was rated significantly better at the sites treated with 70 mJ/MTZ than at the sites treated with 6 mJ/MTZ (p < 0.01). Treatment with 70 mJ/MTZ was significantly more painful than treatment with 6 mJ/MTZ. The typical local reactions to FP, erythema and edema, were also significantly more intense after 70 mJ/MTZ and lasted longer.
FP with higher energy per MTZ at constant total energy input is more effective in the treatment of facial wrinkles than lower energy. The gain in effectiveness is, nonetheless, accompanied by an increase in adverse reactions. The treating physician may use this information to adjust treatment to the preferences of the individual patient.
分段光热分解（FP）用于治疗面部皱纹。
研究不同 FP 治疗参数对面部皱纹治疗的效果。
在一项随机、半脸对照研究中，11 名患者在 4 周间隔内接受了 3 次 FP 治疗。保持每侧面部的总能量输入不变，一侧用 6 mJ/MTZ 进行治疗，MTZ 密度相对较高（高达 2625 MTZ/cm(2)），对侧用 70 mJ/MTZ 进行治疗，MTZ 密度较低（高达 230 MTZ/cm(2)）。末次治疗后 1、3 和 6 个月进行随访（FU）。美容评估由患者自我评估和 3 位独立、盲法评估者评估标准化照片进行。在治疗后 7 天内，患者每天在患者日记中记录治疗后的副作用。
6 个月后，患者自我评估显示皱纹严重度分别从 5.2±1.5 显著改善至 3.8±1.3 和 3.7±1.3（p<0.005），分别用于 6 mJ/MTZ 和 70 mJ/MTZ，但两种能量水平之间无显著差异。相比之下，盲法评估者评估的照片显示，用 70 mJ/MTZ 治疗的部位皱纹严重度明显好于用 6 mJ/MTZ 治疗的部位（p<0.01）。用 70 mJ/MTZ 治疗的疼痛明显高于用 6 mJ/MTZ 治疗的疼痛。典型的 FP 局部反应，如红斑和水肿，在 70 mJ/MTZ 后也明显更强烈，持续时间更长。
在保持总能量输入不变的情况下，每个 MTZ 的能量更高的 FP 治疗面部皱纹比能量较低的治疗更有效。然而，疗效的提高伴随着不良反应的增加。治疗医生可以根据患者的个人喜好调整治疗方案。
