Bhavar Girija, Chatpalliwar V A
Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy, Karvand Naka, Shirpur-425 405, India.
Indian J Pharm Sci. 2008 May-Jun;70(3):395-8. doi: 10.4103/0250-474X.43016.
A simple, accurate and precise HPTLC method has been developed for estimation of propranolol hydrochloride from bulk drug and tablet formulations. The separation was achieved on TLC plates using appropriate solvent system. The spots so developed were densitometrically scanned at 290 nm. The linearity of the method was found to be within the concentration range of 200-2000 ng/spot. The validation parameters, tested in accordance with the requirements of ICH guidelines, prove the suitability of this method. The method was successively applied for determination of drug in tablets, wherein, no interference from tablet excipients was observed.
已开发出一种简单、准确且精密的高效薄层色谱法，用于从原料药和片剂制剂中测定盐酸普萘洛尔。使用合适的溶剂系统在薄层色谱板上实现分离。展开的斑点在290 nm处进行光密度扫描。该方法的线性范围为200 - 2000 ng/斑点。按照国际人用药品注册技术协调会（ICH）指南的要求测试的验证参数，证明了该方法的适用性。该方法连续应用于片剂中药物的测定，在此过程中，未观察到来自片剂辅料的干扰。
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