采用高效液相色谱法测定药物制剂中依巴斯汀的含量。
Determination of ebastine in pharmaceutical formulations by HPLC.
作者信息
Prabu S L, Kumar C Dinesh, Shirwaikar A, Shirwaikar Annie
机构信息
Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India.
出版信息
Indian J Pharm Sci. 2008 May-Jun;70(3):406-7. doi: 10.4103/0250-474X.43022.
Abstract
A simple, precise and rapid RP-HPLC method was developed for the determination of ebastine in pharmaceutical formulations. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm. The linearity range was 5-100 mug/ml. The intra-day and inter-day precision were in the range of 0.22% to 0.49% and 0.24% to 0.73%, respectively.
摘要
建立了一种简单、精确且快速的反相高效液相色谱法（RP-HPLC）用于测定药物制剂中的依巴斯汀。该方法采用菲罗门RP-C18柱，以甲醇和水（90:10）的混合物为流动相，在262 nm波长处进行检测。线性范围为5 - 100 μg/ml。日内精密度在0.22%至0.49%之间，日间精密度在0.24%至0.73%之间。
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