吲哚美辛栓剂的制剂研发与释放研究
Formulation development and release studies of indomethacin suppositories.
作者信息
Sah M L, Saini T R
机构信息
Department of Pharmacy, Shri Govindram Seksaria Institute of Technology and Science, 23, Park Road, Indore-452 003, India.
出版信息
Indian J Pharm Sci. 2008 Jul-Aug;70(4):498-501. doi: 10.4103/0250-474X.44602.
Indomethacin suppositories were prepared by using water-soluble and oil soluble suppository bases, and evaluated for in vitro release by USP I and modified continuous flow through bead bed apparatus. Effect of the Tween 80 (1% and 5%) was further studied on in vitro release of the medicament. Release rate was good in water-soluble suppositories bases in comparison to oil soluble suppositories bases. Release was found to be greater in modified continuous flow through bead bed apparatus. When surfactant was used in low concentration then release rate was much greater, as compared to high concentration. When stability studies were performed on the prepared indomethacin suppositories it was found that suppositories made by water-soluble base had no significant changes while suppositories prepared by oil soluble bases, had some signs of instability.
使用水溶性和油溶性栓剂基质制备吲哚美辛栓剂，并通过美国药典I和改进的连续流过珠床装置评估其体外释放情况。进一步研究了吐温80（1%和5%）对药物体外释放的影响。与油溶性栓剂基质相比，水溶性栓剂基质中的释放速率良好。发现在改进的连续流过珠床装置中释放量更大。当使用低浓度表面活性剂时，与高浓度相比，释放速率要大得多。对制备的吲哚美辛栓剂进行稳定性研究时发现，由水溶性基质制成的栓剂没有明显变化，而由油溶性基质制备的栓剂有一些不稳定迹象。
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