Antony B, Merina B, Sheeba V
R&D Laboratory, Arjuna Natural Extracts Ltd., P.B. No. 126, Bank Road, Alwaye-683 101, India.
Indian J Pharm Sci. 2008 Jul-Aug;70(4):504-7. doi: 10.4103/0250-474X.44604.
Hypercholesterolemia is the major cause of cardiovascular diseases leading to myocardial infarctions leading to considerable morbidity and mortality. During the past decade a group of molecules referred to as statins such as simvastatin, atrovastatin have been tried with great success in reducing total cholesterol. These molecules act by inhibiting the HMG CoA reductase enzyme thereby interfering with the synthesis of cholesterol. But statins reduce all the cholesterol including HDL cholesterol. Long term drug vigilance activity has revealed serious side effects of tendinopathy and related musculoskeletal disorders in some of the subjects. In an effort to manage hypercholesterolemia without serious side effects in a natural way we had tried the use of Amlamax a reconstituted, purified, standardized dried extract of amla (Emblica officinalis) containing 30% ellagitannins with other hydrolysable tannins on humans. We report the hitherto unobserved significant elevation of HDL cholesterol by the administration of Amlamax.
高胆固醇血症是导致心肌梗死进而引发相当高的发病率和死亡率的心血管疾病的主要原因。在过去十年中,一组被称为他汀类药物的分子,如辛伐他汀、阿托伐他汀,在降低总胆固醇方面取得了巨大成功。这些分子通过抑制HMG CoA还原酶来发挥作用,从而干扰胆固醇的合成。但他汀类药物会降低包括高密度脂蛋白胆固醇(HDL胆固醇)在内的所有胆固醇。长期的药物警戒活动揭示了一些受试者出现肌腱病和相关肌肉骨骼疾病等严重副作用。为了以自然的方式管理高胆固醇血症且不产生严重副作用,我们尝试在人体上使用Amlamax,它是一种经过重构、纯化、标准化的余甘子(余甘子)干燥提取物,含有30%的鞣花单宁和其他可水解单宁。我们报告了服用Amlamax后高密度脂蛋白胆固醇出现了迄今未观察到的显著升高。