Syed A A, Syeda Ayesha
Department of Studies in Chemistry, University of Mysore, Mysore-570 006, India.
Indian J Pharm Sci. 2008 Jul-Aug;70(4):507-10. doi: 10.4103/0250-474X.44605.
Spectrophotometric method for the determination of certain proton pump inhibitors belonging to the benzimidazole class of compounds has been developed. The method is based on the reaction of omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole with iron (III) and subsequent reaction with ferricyanide under neutral condition which yields Prussian blue product with maximum absorption at 720-730 nm. The commonly encountered excipients and additives that often accompany pharmaceutical preparations did not interfere with the determination. The method was applied for the determination of omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole in pharmaceutical preparations and no difference was found statistically. Thus, the spectrophotometric method can be applied as inexpensive, rapid, easy, accurate and precise method for the routine analysis of the five proton pump inhibitors in pharmaceutical preparations.
已开发出用于测定某些属于苯并咪唑类化合物的质子泵抑制剂的分光光度法。该方法基于奥美拉唑、兰索拉唑、泮托拉唑、雷贝拉唑和埃索美拉唑与铁（III）的反应，随后在中性条件下与铁氰化物反应，生成在720 - 730 nm处有最大吸收的普鲁士蓝产物。药物制剂中常见的辅料和添加剂不干扰测定。该方法用于测定药物制剂中的奥美拉唑、兰索拉唑、泮托拉唑、雷贝拉唑和埃索美拉唑，统计学上未发现差异。因此，分光光度法可作为一种廉价、快速、简便、准确且精密的方法，用于药物制剂中五种质子泵抑制剂的常规分析。
