缺氧的正电子发射断层扫描成像
Positron Emission Tomography Imaging of Hypoxia.
作者信息
Lapi Suzanne E, Voller Thomas F, Welch Michael J
出版信息
PET Clin. 2009 Jan 1;4(1):39-47. doi: 10.1016/j.cpet.2009.05.009.
Abstract
Hypoxia imaging has applications in functional recovery in ischemic events such as stroke and myocardial ischemia, but especially in tumors in which hypoxia can be predictive of treatment response and overall prognosis. Recently there has been development of imaging agents utilizing positron emission tomography for non-invasive imaging of hypoxia. Many of these PET agents have come to the forefront of hypoxia imaging. Halogenated PET nitroimidazole imaging agents labeled with (18)F (t(1/2) = 110 m) and (124)I (t(1/2) = 110 m) have been under investigation for the last 25 years, with radiometal agents ((64)Cu-ATSM) being developed more recently. This review focuses on these positron emission tomography imaging agents for hypoxia.
摘要
缺氧成像在缺血性事件如中风和心肌缺血的功能恢复中具有应用价值，尤其是在肿瘤中，缺氧可预测治疗反应和总体预后。最近，利用正电子发射断层扫描技术开发了用于缺氧无创成像的显像剂。其中许多正电子发射断层显像剂已成为缺氧成像的前沿技术。标记有（18）F（半衰期 = 110分钟）和（124）I（半衰期 = 110分钟）的卤化正电子发射断层硝基咪唑显像剂在过去25年中一直在研究中，放射性金属显像剂（（64）Cu - ATSM）则是最近才开发出来的。本综述重点关注这些用于缺氧的正电子发射断层扫描显像剂。
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