Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel.
Arch Gynecol Obstet. 2011 Feb;283(2):219-22. doi: 10.1007/s00404-009-1332-5. Epub 2010 Jan 3.
The cause of striae gravidarum is still unclear. The study objective was to test the hypothesis that relaxin is involved in the process of striae gravidarum appearance during pregnancy.
A prospective observational study in 32 pregnant women. Participants were observed at 12th, 24th and 36th gestational week. During each session, striae scoring was assessed and blood for relaxin estimation was withdrawn. The striae assessment was done according to Davey score. Serum relaxin was estimated using Relaxin ELISA kit (Immunodiagnostic AG, Bensheim, Germany).
Serum relaxin levels decreased as the pregnancy advanced (585.9 ± 295.1, 424.2 ± 253.8, 402.1 ± 221.2 pg/ml, respectively) but this decrease did not attain statistical significance. Pregnant women with striae gravidarum had lower serum relaxin levels compared to those without striae gravidarum at 36th gestational weeks, 330.8 ± 175.2 vs 493.8 ± 245.8 pg/ml (P = 0.037), respectively. The severity of striae gravidarum during pregnancy did not correlate with serum relaxin levels.
Lower serum relaxin levels could contribute to the occurrence of striae gravidarum during pregnancy through decreased elasticity of the connective tissue.
妊娠纹的成因仍不清楚。本研究旨在验证松弛素参与妊娠纹形成的假设。
对 32 名孕妇进行前瞻性观察研究。在第 12、24 和 36 孕周观察参与者。每次就诊时，评估妊娠纹评分并采集松弛素检测血样。妊娠纹评估根据 Davey 评分进行。使用 Relaxin ELISA 试剂盒（德国宾海姆的 Immunodiagnostic AG）检测血清松弛素。
随着妊娠的进展，血清松弛素水平下降（分别为 585.9 ± 295.1、424.2 ± 253.8、402.1 ± 221.2 pg/ml），但这种下降无统计学意义。在 36 孕周时，有妊娠纹的孕妇血清松弛素水平低于无妊娠纹的孕妇，分别为 330.8 ± 175.2 和 493.8 ± 245.8 pg/ml（P = 0.037）。妊娠纹的严重程度与血清松弛素水平无关。
血清松弛素水平降低可能通过降低结缔组织的弹性导致妊娠纹的发生。
