[叶酸干预对神经管缺陷影响的Meta分析]
[Meta-analysis of effect of intervention with folic acid on neural tube defects].
作者信息
Jian Mingzhi, Wang Jintao, Sun Haikui
机构信息
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
出版信息
Wei Sheng Yan Jiu. 2009 Nov;38(6):682-4.
OBJECTIVE
To provide evidences for decision-making on neural tube defects prevention according to evaluating the effect of intervention with 0.4 mg folic acid on the incidence of neural tube defects in China.
METHODS
Meta-analysis with software of Review Manager 4.2 version was used to synthetically and quantitatively evaluate the studies included. The Peto method of fixed effect model and random effect model (DerSimonin and Laird) were applied to estimate combined effect values and their corresponding 95% confidence intervals of homogenous and inhomogenous data respectively.
RESULTS
Six pieces of literature included in which the studies were folic acid intervention were inhomogenous (chi2 = 13.43, P = 0. 02). Random effect model of Meta-analysis method were used. The combined effect values of intervention with folic acid on neural tube defects among women were strikingly significance (Z = 5.17, P = 0.00001). The pooled RR values were 0.36 (95% CI: 0.25-0.53).
CONCLUSION
Intervention with folic acid on neural tube defects are effective.
目的
通过评估0.4mg叶酸干预对中国神经管缺陷发生率的影响，为神经管缺陷预防决策提供依据。
方法
采用RevMan 4.2版软件进行Meta分析，对纳入研究进行综合定量评价。分别应用固定效应模型的Peto法和随机效应模型（DerSimonin和Laird法）估计同质和异质数据的合并效应值及其相应的95%置信区间。
结果
纳入6篇叶酸干预研究的文献，研究存在异质性（χ2 = 13.43，P = 0.02）。采用Meta分析方法的随机效应模型。叶酸干预对女性神经管缺陷的合并效应值具有显著意义（Z = 5.17，P = 0.00001）。合并RR值为0.36（95%CI：0.25 - 0.53）。
结论
叶酸干预神经管缺陷有效。
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