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慢性免疫抑制剂硫唑嘌呤治疗重症肌无力患者的沙门氏菌脑脓肿:报告一例不常见病例,并复习后抗生素时代的文献。

Salmonella brain abscess in a patient on chronic azathioprine therapy for myasthenia gravis: report of an unusual case and review of literature in the postantibiotic era.

机构信息

Mason Eye Institute, Department of Ophthalmology, University of Missouri, Columbia, MO 65212, USA.

出版信息

J Neurovirol. 2010 Feb;16(1):83-92. doi: 10.3109/13550280903493906.

Abstract

Focal intracranial infections caused by Salmonella species in adults are exceedingly uncommon. Structural brain injury with coexisting immunocompromised status appears to predispose adults to this rare manifestation of Salmonella infection. We report a case of Salmonella brain abscess in a patient with myasthenia gravis on chronic azathioprine therapy without any prior structural brain lesion. We reviewed world literature and discuss their analysis of Salmonella brain abscess in adult population in the postantibiotic era.

摘要

成人因沙门氏菌属引起的局灶性颅内感染极为罕见。伴有免疫功能低下的结构性脑损伤似乎使成人易患这种罕见的沙门氏菌感染。我们报告一例重症肌无力患者在接受慢性硫唑嘌呤治疗时发生沙门氏菌脑脓肿,该患者无任何先前的结构性脑损伤。我们复习了世界范围内的文献,并讨论了在后抗生素时代成人沙门氏菌脑脓肿的分析。

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