Department of Obstetrics and Gynecology, Provincial Hospital affiliated to Shandong University, Jinan, China.
Am J Reprod Immunol. 2010 Mar 1;63(3):189-92. doi: 10.1111/j.1600-0897.2009.00789.x. Epub 2009 Dec 29.
Pregnancy-related disease is a common challenging clinical problem. From our review and clinical experience, we hypothesize that many severe pregnancy-related complications might be caused by a fetal-versus-maternal disease (FVMD), based on the fact that maternal disease is related to immunity and that fetal cells are present in maternal blood. Fetus is a semi-antigen and can be considered as a tumor or graft. The pathophysiology of FVMD must be complex. We speculate it to be a three-step process: impaired maternal immunological function, fetal T-cell activation and injury of target organs. More experiments and research will be needed to prove our hypothesis.
妊娠相关疾病是一个常见的临床难题。通过我们的回顾和临床经验，我们假设许多严重的妊娠相关并发症可能是由胎儿与母体疾病（FVMD）引起的，这基于以下事实：母体疾病与免疫有关，并且胎儿细胞存在于母体血液中。胎儿是半抗原，可以被视为肿瘤或移植物。FVMD 的病理生理学必然是复杂的。我们推测它是一个三步过程：母体免疫功能受损、胎儿 T 细胞激活和靶器官损伤。需要更多的实验和研究来验证我们的假设。
