人类妊娠的免疫紊乱
Immunological disorders of human pregnancy.
作者信息
Redman C W, Sargent I L
出版信息
Oxf Rev Reprod Biol. 1986;8:223-65.
PMID:3540804
Abstract
Three types of disorders of human pregnancy with a possible immune etiology have been discussed. Pre-eclampsia and recurrent abortion may result from a failure of a maternal immunoregulatory response to trophoblast but the evidence is incomplete and circumstantial. There are several fetal problems which may arise because of transfer of maternal allo-, iso-, or autoantibodies to the fetus. Third, maternal graft-versus-fetal-host disease occurs rarely and may present in a delayed and incomplete way as severe combined immunodeficiency.
摘要
本文讨论了三种可能由免疫病因引起的人类妊娠疾病。先兆子痫和复发性流产可能是由于母体对滋养层的免疫调节反应失败所致，但证据并不完整且具有间接性。由于母体同种、自身或自身抗体转移至胎儿，可能会引发一些胎儿问题。第三，母源性移植物抗胎儿宿主病很少发生，可能会以严重联合免疫缺陷的形式延迟且不完全地表现出来。
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