Department of Community Health Sciences, Faculty of Medicine, University of Calgary, and Hotchkiss Brain Institute, Calgary, Alberta.
Can J Psychiatry. 2009 Dec;54(12):841-5. doi: 10.1177/070674370905401207.
Numerous surveys have reported associations between major depressive episodes (MDEs) and occupational status, but cross-sectional studies cannot quantify the risks of employment transitions nor clarify their temporal direction. The goal of our study was to estimate the impact of MDE on subsequent employment status in a longitudinal community cohort.
Data from the National Population Health Survey (NPHS) were used. Proportional hazard models and logistic regression were employed to evaluate the effect of MDE on working status during the 1994 to 2004 interval among respondents who reported working at a job or business at baseline.
MDE was associated with an increased risk of movement to nonworking status. People aged 26 to 45 years with MDEs have more than double the risk of this transition (HR = 2.6; 95% CI 1.8 to 3.6, P < 0.001). The probability of transition to nonworking status was higher, but the relative effect was smaller in people aged 46 to 65 years (HR = 1.2; 95% CI 0.7 to 2.0, P = 0.47). Retirement or perceived lack of availability of work did not contribute to the association.
MDE is associated with an elevated risk of transition from working to nonworking status, especially in people aged 26 to 45 years.
许多调查都报告了重度抑郁发作（MDE）与职业状况之间的关联，但横断面研究无法量化就业转型的风险，也无法阐明其时间方向。我们的研究目的是在纵向社区队列中估计 MDE 对随后就业状况的影响。
使用了全国人口健康调查（NPHS）的数据。采用比例风险模型和逻辑回归来评估在 1994 年至 2004 年期间，报告在基线时从事工作或业务的受访者中，MDE 对工作状况的影响。
MDE 与向非工作状态转变的风险增加有关。患有 MDE 的 26 至 45 岁人群的这种转变风险增加了两倍多（HR = 2.6；95%CI 1.8 至 3.6，P < 0.001）。46 至 65 岁人群的过渡到非工作状态的可能性更高，但相对效果较小（HR = 1.2；95%CI 0.7 至 2.0，P = 0.47）。退休或认为工作机会不足并不促成这种关联。
MDE 与从工作状态向非工作状态转变的风险增加有关，尤其是在 26 至 45 岁的人群中。
