骨形态发生蛋白：人类BMP1、BMP2A和BMP3基因的染色体定位
Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3.
作者信息
Tabas J A, Zasloff M, Wasmuth J J, Emanuel B S, Altherr M R, McPherson J D, Wozney J M, Kaplan F S
机构信息
Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia.
出版信息
Genomics. 1991 Feb;9(2):283-9. doi: 10.1016/0888-7543(91)90254-c.
Bone morphogenetic protein (BMP) induces endochondral bone formation in vivo. The human genes have been cloned for a group of proteins containing BMP activity (BMP1, BMP2A, and BMP3). Two of the proteins are members of the transforming growth factor-beta supergene family (BMP2A and BMP3), while BMP1 is a novel regulatory protein. Using somatic cell hybrid lines, cDNA probes were used to map BMP1 to chromosome 8, BMP2A to chromosome 20, and BMP3 to the p14-q21 region of chromosome 4. This analysis reveals that the BMP2A and BMP3 genes map to conserved regions between mouse and human, while the BMP1 gene does not. The locations of the BMP genes were found to overlap with the loci for several disorders of cartilage and bone formation.
骨形态发生蛋白（BMP）在体内诱导软骨内成骨。已克隆出一组具有BMP活性的人类基因（BMP1、BMP2A和BMP3）。其中两种蛋白质是转化生长因子-β超基因家族的成员（BMP2A和BMP3），而BMP1是一种新型调节蛋白。利用体细胞杂交系，使用cDNA探针将BMP1定位到8号染色体，BMP2A定位到20号染色体，BMP3定位到4号染色体的p14-q21区域。该分析表明，BMP2A和BMP3基因定位于小鼠和人类之间的保守区域，而BMP1基因则不然。发现BMP基因的位置与几种软骨和骨形成障碍的基因座重叠。
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