Xu J, Hardison R C
Department of Molecular and Cell Biology, Pennsylvania State University, University Park 16802.
Genomics. 1991 Feb;9(2):362-5. doi: 10.1016/0888-7543(91)90265-g.
The rabbit (Oryctolagus cuniculus) alpha-like globin gene cluster (HBAC) contains several block duplications of zeta-, alpha and theta-globin genes. Using in situ hybridizations to metaphase chromosome spreads, the gene cluster has been mapped to region q12 of chromosome 6. Given that human HBAC maps to the short arm of chromosome 16, the mapping of rabbit HBAC to 6q12 confirms the assignment of homology between OCU6q and HSA16p based on similarities of chromosomal banding patterns. In both species, HBAC is in a very G + C-rich region within the most distal band of the chromosome.
兔（穴兔）α-类珠蛋白基因簇（HBAC）包含几个ζ-、α-和θ-珠蛋白基因的区段重复。通过对中期染色体铺展进行原位杂交，该基因簇已被定位到6号染色体的q12区域。鉴于人类HBAC定位于16号染色体的短臂，兔HBAC定位于6q12证实了基于染色体带型相似性，在兔6号染色体长臂远侧带与人类16号染色体短臂之间存在同源性。在这两个物种中，HBAC都位于染色体最远端带内一个富含鸟嘌呤和胞嘧啶的区域。
