N-戊基泛酰胺的抗菌活性源于对辅酶 A 合成的抑制。
Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme a synthesis.
机构信息
Departments of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
出版信息
Antimicrob Agents Chemother. 2010 Mar;54(3):1374-7. doi: 10.1128/AAC.01473-09. Epub 2010 Jan 4.
Abstract
Growth inhibition by the pantothenate analog N-pentylpantothenamide (N5-Pan) has been attributed to the accumulation of acyl carrier protein carrying a prosthetic group modified by incorporation of N5-Pan. This was attributed to an inability of the AcpH acyl carrier protein phosphodiesterase to cleave the N5-Pan-modified prosthetic group from the protein moiety. We report that AcpH readily removes the N5-Pan-modified prosthetic group both in vivo and in vitro and show that N5-Pan blocks coenzyme A synthesis.
摘要
泛酸类似物 N-戊基泛酰胺（N5-Pan）的生长抑制作用归因于酰基载体蛋白（携带通过掺入 N5-Pan 修饰的辅基）的积累。这归因于 AcpH 酰基载体蛋白磷酸二酯酶无法从蛋白质部分切割 N5-Pan 修饰的辅基。我们报告说，AcpH 可以在体内和体外迅速去除 N5-Pan 修饰的辅基，并表明 N5-Pan 阻断辅酶 A 的合成。
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