内侧下丘脑在调节垂体-肾上腺皮质系统中的作用
[Role of the medial hypothalamus in regulating the pituitary-adrenocortical system].
作者信息
Filaretov A A, Rakitskaia V V
出版信息
Fiziol Zh SSSR Im I M Sechenova. 1977 Oct;63(10):1407-10.
PMID:200496
Abstract
In unrestrained rabbits, inhibition of ACTH release as determined by changes in plasma levels of corticosteroids, followed electrolytic lesion of the dorso-and ventromedia nuclei of the hypothalamus. Electric stimulation of the dorsal midbrain tegmentum had activated ACTH prior to lesion; after the lesion of the dorso-and ventromedial nuclei the stimulation produced no response. The dorso-and ventromedial nuclei of the hypothalamus are essential for basal and induced secretion of the ACTH.
摘要
在未受限制的兔子中，通过皮质类固醇血浆水平的变化来确定促肾上腺皮质激素（ACTH）释放的抑制，这种抑制发生在下丘脑背内侧核和腹内侧核的电解损伤之后。在损伤之前，电刺激中脑背侧被盖可激活促肾上腺皮质激素；在背内侧核和腹内侧核损伤后，该刺激不再产生反应。下丘脑的背内侧核和腹内侧核对于促肾上腺皮质激素的基础分泌和诱导分泌至关重要。
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