具有莽草酸头基的阳离子两亲分子作为树突状细胞基于基因免疫的 DNA 疫苗载体比其甘露糖类似物具有更大的系统优势。

Cationic amphiphile with shikimic acid headgroup shows more systemic promise than its mannosyl analogue as DNA vaccine carrier in dendritic cell based genetic immunization.

机构信息

Division of Lipid Science and Technology, Indian Institute of Chemical Technology, Hyderabad 500 007, India.

出版信息

J Med Chem. 2010 Feb 11;53(3):1387-91. doi: 10.1021/jm901295s.

PMID:20050668

Abstract

Mannosylated cationic vectors have been previously used for delivering DNA vaccines to antigen presenting cells (APCs) via mannose receptors expressed on the cell surface of APCs. Here we show that cationic amphiphiles containing mannose-mimicking quinic acid and shikimic acid headgroups deliver genes to APCs via mannose receptor. Cationic amphiphile with shikimic acid headgroup was more efficacious than its mannosyl counterpart in combating mouse tumor growth by dendritic cell (the most professional APC) based genetic immunization.

摘要

甘露糖基阳离子载体以前曾被用于通过 APC 表面表达的甘露糖受体将 DNA 疫苗递送至抗原呈递细胞（APCs）。在这里，我们表明，含有模拟甘露糖的奎尼酸和莽草酸头基的阳离子两亲物通过甘露糖受体将基因递送至 APC。具有莽草酸头部的阳离子两亲物比其甘露糖对应物在基于树突状细胞（最专业的 APC）的基因免疫中更有效地抵抗小鼠肿瘤生长。