甘露糖模拟莽草酸酯基与喹啉酰头基之间间隔长度的增加以及阳离子两亲物疏水区域的增强提高了基于树突状细胞的DNA疫苗接种效率：一项构效关系研究。

Enhanced Spacer Length between Mannose Mimicking Shikimoyl and Quinoyl Headgroups and Hydrophobic Region of Cationic Amphiphile Increases Efficiency of Dendritic Cell Based DNA Vaccination: A Structure-Activity Investigation.

作者信息

Voshavar Chandrashekhar, Meka Rakesh C R, Samanta Sanjoy, Marepally Srujan, Chaudhuri Arabinda

机构信息

Biomaterials Group, CSIR-Indian Institute of Chemical Technology , Hyderabad 500 007, India.

Academy of Scientific and Innovative Research (AcSIR) , Taramani, Chennai 600 113, India.

出版信息

J Med Chem. 2017 Feb 23;60(4):1605-1610. doi: 10.1021/acs.jmedchem.6b01556. Epub 2017 Feb 10.

DOI:10.1021/acs.jmedchem.6b01556

PMID:28124909

Abstract

In the field of dendritic cell based genetic immunization, previously we showed that liposomes of cationic amphiphiles containing mannose-mimicking shikimoyl headgroup are promising DNA vaccine carriers for dendritic cell (DC) transfection. The present structure-activity study reports on the influence of spacer length (between mannose-mimicking headgroups and quaternary nitrogen centers) in modulating the DC-transfection efficiencies. Further, we report on the anti-melanoma immune response inducing properties of the promising cationic amphiphiles in syngeneic C57BL/6J mice under prophylactic settings.

摘要

在基于树突状细胞的基因免疫领域，我们之前表明，含有模拟甘露糖的莽草酸酯头基的阳离子两亲性脂质体是用于树突状细胞（DC）转染的有前景的DNA疫苗载体。本结构-活性研究报道了间隔长度（在模拟甘露糖的头基和季氮中心之间）对调节DC转染效率的影响。此外，我们报道了在预防性设置下，有前景的阳离子两亲性分子在同基因C57BL/6J小鼠中诱导抗黑色素瘤免疫反应的特性。