α-羟基异己酸对运动员身体成分、延迟性肌肉酸痛和运动表现的影响。
Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes.
机构信息
Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland.
出版信息
J Int Soc Sports Nutr. 2010 Jan 5;7:1. doi: 10.1186/1550-2783-7-1.
BACKGROUND
Alfa-Hydroxy-isocaproic acid (HICA) is an end product of leucine metabolism in human tissues such as muscle and connective tissue. According to the clinical and experimental studies, HICA can be considered as an anti-catabolic substance. The present study investigated the effects of HICA supplementation on body composition, delayed onset of muscle soreness (DOMS) and physical performance of athletes during a training period.
METHODS
Fifteen healthy male soccer players (age 22.1+/-3.9 yr) volunteered for the 4-week double-blind study during an intensive training period. The subjects in the group HICA (n = 8) received 583 mg of sodium salt of HICA (corresponding 500 mg of HICA) mixed with liquid three times a day for 4 weeks, and those in the group PLACEBO (n = 7) received 650 mg of maltodextrin mixed with liquid three times a day for the same period. According to a weekly training schedule, they practiced soccer 3 - 4 times a week, had strength training 1 - 2 times a week, and had one soccer game during the study. The subjects were required to keep diaries on training, nutrition, and symptoms of DOMS. Body composition was evaluated with a dual-energy X-ray absorptiometry (DXA) before and after the 4-week period. Muscle strength and running velocity were measured with field tests.
RESULTS
As compared to placebo, the HICA supplementation increased significantly body weight (p < 0.005) and whole lean body mass (p < 0.05) while fat mass remained constant. The lean body mass of lower extremities increased by 400 g in HICA but decreased by 150 g in PLACEBO during the study. This difference between the groups was significant (p < 0.01). The HICA supplementation decreased the whole body DOMS symptoms in the 4(th )week of the treatment (p < 0.05) when compared to placebo. Muscle strength and running velocity did not differ between the groups.
CONCLUSION
Already a 4-week HICA supplementation of 1.5 g a day leads to small increases in muscle mass during an intensive training period in soccer athletes.
背景
阿尔法-羟基异己酸（HICA）是人体组织（如肌肉和结缔组织）中亮氨酸代谢的终产物。根据临床和实验研究，HICA 可以被认为是一种抗分解代谢物质。本研究调查了 HICA 补充剂对运动员在训练期间的身体成分、延迟性肌肉酸痛（DOMS）和身体表现的影响。
方法
15 名健康男性足球运动员（年龄 22.1+/-3.9 岁）在强化训练期间自愿参加了为期 4 周的双盲研究。HICA 组（n=8）的受试者每天服用 583 毫克 HICA 的钠盐（相当于 500 毫克 HICA），混合在液体中，分三次服用，持续 4 周，而安慰剂组（n=7）每天服用 650 毫克麦芽糊精，混合在液体中，持续相同时间。根据每周的训练计划，他们每周踢 3-4 次足球，每周进行 1-2 次力量训练，在研究期间进行 1 次足球比赛。要求受试者记录训练、营养和 DOMS 症状的日记。在 4 周后使用双能 X 射线吸收仪（DXA）评估身体成分。使用现场测试测量肌肉力量和跑步速度。
结果
与安慰剂相比，HICA 补充剂可显著增加体重（p < 0.005）和全身瘦体重（p < 0.05），而脂肪量保持不变。HICA 组下肢瘦体重增加 400 克，而安慰剂组减少 150 克。两组之间的差异具有统计学意义（p < 0.01）。与安慰剂相比，HICA 补充剂可减少治疗第 4 周时的全身 DOMS 症状（p < 0.05）。两组之间的肌肉力量和跑步速度没有差异。
结论
在足球运动员的强化训练期间，每天补充 1.5 克 HICA 即可导致肌肉质量的小幅增加。
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