Department of Medicine, College of Medicine, University of Lagos, Nigeria.
BMC Neurol. 2010 Jan 5;10:1. doi: 10.1186/1471-2377-10-1.
Current data on the pattern of parkinsonism and Parkinson's disease in Nigerians are sparse.This database was designed to document the clinical profile of PD in Nigerians, and compare this to prior observations.
A database of patients presenting to the Neurology out-patients clinic of the Lagos University Teaching Hospital was established in October 1996. Demographic and clinical data at presentation (disease stage using Hoehn and Yahr scale; 'off' state severity on the Unified Parkinson's disease Rating Scale) were documented for patients diagnosed with parkinsonism between October 1996 and December 2006. Cases were classified as Parkinson's disease or secondary parkinsonism (in the presence of criteria suggestive of a secondary aetiology).
The hospital frequency of parkinsonism (over a 2-year period, and relative to other neurologic disorders) was 1.47% (i.e. 20/1360). Of the 124 patients with parkinsonism, 98 (79.0%) had PD, while 26 (21.0%) had secondary parkinsonism. Mean age (SD) at onset of PD (61.5 (10.0) years) was slightly higher than for secondary parkinsonism (57.5 (14.0) years) (P = 0.10). There was a male preponderance in PD (3.3 to 1) and secondary parkinsonism (2.7 to 1), while a positive family history of parkinsonism was present in only 1.02% (1/98) of PD. There was a modestly significant difference in age at onset (SD) of PD in men (60.3 (10.4)) compared to women (65.2 (7.9)) (T = 2.08; P = 0.04). The frequency of young onset PD (< or = 50 years) was 16.3% (16/98). The mean time interval from onset of motor symptoms to diagnosis of PD was 24.6 +/- 26.1 months with majority presenting at a median 12 months from onset. On the H&Y scale, severity of PD at presentation was a median 2.0 (range 1 to 4). PD disease subtype was tremor-dominant in 31 (31.6%), mixed 54 (55.1%) and akinetic-rigid 14 (14.3%). Hypertension was present as a co-morbidity in 20 (20.4%), and diabetes in 6 (6.12%).
The clinical profile of PD in Nigerians is similar to that in other populations, but is characterized by delayed presentation as has been reported in other developing countries. Young-onset disease occurs but may be less commonly encountered, and frequency of a positive family history is lower than in western populations.
目前有关尼日利亚人中帕金森病和帕金森病模式的资料很少。本数据库旨在记录尼日利亚人中 PD 的临床特征，并将其与以往的观察结果进行比较。
1996 年 10 月，在拉各斯大学教学医院神经科门诊建立了患者数据库。记录了 1996 年 10 月至 2006 年 12 月期间诊断为帕金森病患者的人口统计学和临床特征（使用 Hoehn 和 Yahr 量表评估疾病阶段；使用统一帕金森病评定量表评估“关闭”状态严重程度）。将病例分为帕金森病或继发性帕金森病（存在提示继发性病因的标准）。
（在两年期间，相对于其他神经疾病）医院帕金森病的发病率为 1.47%（即 20/1360）。在 124 例帕金森病患者中，98 例（79.0%）为 PD，26 例（21.0%）为继发性帕金森病。PD 的发病年龄（SD）（61.5（10.0）岁）略高于继发性帕金森病（57.5（14.0）岁）（P=0.10）。PD 中男性患病率（3.3 比 1）和继发性帕金森病（2.7 比 1）均高于女性，而 PD 家族史阳性仅占 98 例（1.02%）（1/98）。男性 PD 的发病年龄（SD）（60.3（10.4）岁）与女性（65.2（7.9）岁）相比，差异具有统计学意义（T=2.08，P=0.04）。早发性 PD（<或=50 岁）的频率为 16.3%（16/98）。从运动症状发作到 PD 诊断的平均时间间隔为 24.6+/-26.1 个月，大多数患者在发作后 12 个月内就诊。H&Y 量表上，PD 发病时的严重程度为中位数 2.0（范围 1 至 4）。PD 疾病亚型为震颤占优势 31 例（31.6%），混合 54 例（55.1%）和无动性震颤占优势 14 例（14.3%）。高血压为 20 例（20.4%）的合并症，糖尿病为 6 例（6.12%）。
尼日利亚 PD 的临床特征与其他人群相似，但表现为就诊延迟，这在其他发展中国家也有报道。早发性疾病虽有发生，但可能不太常见，家族史阳性率低于西方人群。
