Aygun Dursun, Turkel Yakup, Onar Musa Kazım, Sunter Tevfik
Ondokuz Mayis University, Medical School, Department of Nurology, Samsun, Turkey.
Ondokuz Mayis University, Medical School, Department of Nurology, Samsun, Turkey.
Clin Neurol Neurosurg. 2014 Apr;119:54-8. doi: 10.1016/j.clineuro.2014.01.011. Epub 2014 Jan 24.
Studies documenting the association between rapid eye movement sleep behavior disorder (RBD) and motor subtypes in Parkinson's disease (PD) are rare. Our hypothesis is that RBD may be more severe in non-tremor dominant (NTD) patients with RBD than those tremor dominant (TD) with RBD. In this study, we investigated the association between motor subtypes and clinical RBD in PD.
We evaluated 104 consecutive patients older than 18 years presenting with PD to the Neurology Clinic of the University Hospital for one year in this study. The clinical diagnosis of RBD was based on the minimal diagnostic criteria of International Classification of Sleep Disorders, revised. The Stavanger Sleepiness Questionnaire was used to rate the severity of clinical RBD. The patients were divided into two subgroups as TD and NTD. The patient and control groups were compared with each other for severity and frequency of clinical RBD, and the Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn-Yahr stage scores. The correlation between severity of clinical RBD and clinical severity of PD was analyzed in the patient groups.
Of the patients, 45.2% (n=47) had the NTD subtype of PD and 54.8% (n=57) had the TD subtype of PD. There was no significant difference among the groups in terms of frequency and severity of clinical RBD. For the NTD patients, there was a weak positive correlation between severity of clinical RBD and clinical severity of PD. However, there was no correlation in the TD subgroup.
In our study, frequency of clinical RBD was unrelated to motor subtypes of PD. However, in the present study, we found a weak correlation between clinical severity (UPDRS and the Hoehn-Yahr) of PD and severity of clinical RBD in the NTD subtype but not in the TD subtype.
记录快速眼动睡眠行为障碍（RBD）与帕金森病（PD）运动亚型之间关联的研究很少。我们的假设是，患有RBD的非震颤为主型（NTD）患者的RBD可能比震颤为主型（TD）患者更严重。在本研究中，我们调查了PD运动亚型与临床RBD之间的关联。
在本研究中，我们评估了连续104名年龄大于18岁、因PD就诊于大学医院神经科门诊一年以上的患者。RBD的临床诊断基于修订后的《国际睡眠障碍分类》的最低诊断标准。使用斯塔万格嗜睡问卷对临床RBD的严重程度进行评分。患者被分为TD和NTD两个亚组。比较患者组和对照组临床RBD的严重程度和频率，以及统一帕金森病评定量表（UPDRS）和 Hoehn-Yahr分期评分。分析患者组中临床RBD严重程度与PD临床严重程度之间的相关性。
患者中，45.2%（n = 47）为NTD亚型的PD，54.8%（n = 57）为TD亚型的PD。各组之间临床RBD的频率和严重程度无显著差异。对于NTD患者，临床RBD严重程度与PD临床严重程度之间存在弱正相关。然而，TD亚组中无相关性。
在我们的研究中，临床RBD的频率与PD的运动亚型无关。然而，在本研究中，我们发现NTD亚型而非TD亚型中，PD的临床严重程度（UPDRS和Hoehn-Yahr）与临床RBD的严重程度之间存在弱相关性。
