Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, Maryland, USA.
Cancer Prev Res (Phila). 2010 Jan;3(1):1-3. doi: 10.1158/1940-6207.CAPR-09-0245.
This perspective places the article by Tang et al. in this issue of the journal (beginning on page 25) in the context of recent work defining the hedgehog signaling pathway as a central etiologic factor and as a therapeutic target in basal cell cancer. Tang et al. show that inhibition of cyclooxygenase activity, either genetically (in a relevant mouse model) or pharmacologically (in the mouse and in patients highly predisposed to develop basal cell skin cancers), may suppress basal cell carcinogenesis. This new study of cyclooxygenase inhibition, together with recent data on the efficacy of hedgehog pathway inhibition, offers new hope for patients at a high risk for basal cell cancer.
这一看法将唐等人在本期杂志上发表的文章（从第 25 页开始）置于最近的工作背景下，这些工作定义了刺猬信号通路是基底细胞癌的主要病因和治疗靶点。唐等人表明，抑制环氧化酶活性，无论是通过遗传（在相关的小鼠模型中）还是通过药理学（在小鼠和易患基底细胞皮肤癌的患者中），都可能抑制基底细胞癌的发生。这项关于环氧化酶抑制的新研究，以及最近关于刺猬信号通路抑制疗效的数据，为基底细胞癌高危患者带来了新的希望。
