Matsumoto Yoshihiro, Torimoto Kazumasa, Matsuyoshi Hiroko, Hirayama Akihide, Fujimoto Kiyohide, Yoshimura Naoki, Hirao Yoshihiko
Department of Urology, School of Medicine, Nara Medical University, Kashihara, Japan.
Biomed Res. 2009 Dec;30(6):331-5. doi: 10.2220/biomedres.30.331.
The spontaneously diabetic Torii (SDT) rat has recently been established as a model of type 2 diabetes mellitus (DM). The usefulness of this rat model for the study of diabetic voiding dysfunction was investigated. Male SDT rats and male Sprague-Dawley (SD) rats were used. Voiding function was evaluated by a metabolic cage study and cystometry. Total voided volume for 24 h, mean voided volume, and urinary frequency for 24 h were significantly greater in SDT rats at the age of 36 weeks. From cystometry mean inter-micturition interval (IMI) was significantly longer in SDT rats at the age of 22 and 36 weeks. In SDT rats mean IMI was significantly longer at the age of 36 weeks than at the age of 22 weeks. Mean voiding pressure was significantly higher in SDT rats at the age of 22 and 36 weeks. In the present study, SDT rats showed typical diabetic voiding dysfunction similar to other diabetic rat models. It was suggested that activity of the bladder afferent pathways is decreased and the urethral relaxation mechanism is impaired in SDT rats. In addition, SDT rats are suitable to study chronic diabetic voiding dysfunction because they survive without insulin treatment for as long as 60 weeks.
自发性糖尿病鸟居（SDT）大鼠最近被确立为2型糖尿病（DM）模型。本研究探讨了该大鼠模型在糖尿病性排尿功能障碍研究中的实用性。使用雄性SDT大鼠和雄性斯普拉格-道利（SD）大鼠。通过代谢笼实验和膀胱测压评估排尿功能。36周龄的SDT大鼠24小时总排尿量、平均排尿量和24小时排尿频率显著更高。膀胱测压显示，22周龄和36周龄的SDT大鼠平均排尿间隔时间（IMI）显著更长。在SDT大鼠中，36周龄时的平均IMI比22周龄时显著更长。22周龄和36周龄的SDT大鼠平均排尿压力显著更高。在本研究中，SDT大鼠表现出与其他糖尿病大鼠模型相似的典型糖尿病性排尿功能障碍。提示SDT大鼠膀胱传入通路活性降低，尿道松弛机制受损。此外，SDT大鼠适合用于研究慢性糖尿病性排尿功能障碍，因为它们无需胰岛素治疗即可存活长达60周。
