Isaac Anjeli Krishnan, Lertsburapa Terakeith, Pathria Mundi Jyoti, Martini Mary, Guitart Joan, Gerami Pedram
Department of Dermatology, Northwestern University, Chicago, IL, USA.
Am J Dermatopathol. 2010 Apr;32(2):144-8. doi: 10.1097/DAD.0b013e3181b72d6f.
Fluorescence in situ hybridization (FISH) often reveals imbalanced chromosomal gains in melanoma, whereas Spitz nevi typically have a normal complement of chromosomes. However, there may be a subset of Spitz nevi that are perfectly tetraploid by FISH analysis, and these cases may be confused diagnostically with melanoma. This study evaluates 41 cases of Spitz nevi that were histologically confirmed to be benign. Four of these lesions demonstrated polyploidy by FISH. Three of the 4 cases were from the same patient, a 17-year-old woman; 1 lesion was from the wrist, whereas the other 2 were from the buttocks. The other case was from a 14-year-old man from the ankle. All 4 cases that were polyploid were confirmed using a probe for the X chromosome. This article highlights the importance of polyploidy as a feature of some benign Spitz nevi.
荧光原位杂交（FISH）常常显示黑色素瘤存在染色体获得失衡的情况，而Spitz痣通常具有正常的染色体组成。然而，通过FISH分析可能存在一部分Spitz痣是完全四倍体，这些病例在诊断上可能会与黑色素瘤混淆。本研究评估了41例经组织学证实为良性的Spitz痣。其中4个病变通过FISH显示为多倍体。这4例中的3例来自同一名17岁女性患者；1个病变位于腕部，另外2个位于臀部。另一例来自一名14岁男性患者的脚踝。所有4例多倍体病例均使用X染色体探针进行了确认。本文强调了多倍体作为一些良性Spitz痣特征的重要性。
