Department of Ophthalmology, Tulane School of Medicine, Tulane University, Xavier University of Louisiana, New Orleans, LA 70112, USA.
J Glaucoma. 2010 Sep;19(7):456-9. doi: 10.1097/IJG.0b013e3181c4ae92.
To measure and compare the surface tension of aqueous humor in patients with and without glaucoma.
The surface tension of aqueous humor was measured using a commercially available instrument and software that were validated by using a known fluid (deionized water and methanol). Analysis of aqueous and vitreous samples obtained from 20 rabbit eyes showed that the system could be used successfully for small amounts of ocular fluid. The effect of glaucoma drugs on the surface tension of aqueous humor was then studied in a rabbit model. Comparison of aqueous humor from 66 patients with glaucoma and 53 patients with cataracts but no glaucoma was carried out.
The surface tension of rabbit aqueous humor was 65.9 ± 1.2; vitreous, 60.6 ± 2.6; and balanced salt solution, 70.7 ± 0.9. Timolol and latanoprost did not alter the surface tension of the aqueous humor in the rabbit model. The average surface tension of human aqueous humor was 63.33 ± 4.0 (glaucomatous eyes) and 66.19 ± 2.64 (nonglaucomatous eyes with cataracts) (P=0.0001).
A technique of measuring the surface tension from small quantities of aqueous humor is validated. Surface tension of the aqueous humor in glaucoma patients was less than that of cataract patients.
测量并比较青光眼患者和非青光眼患者房水的表面张力。
使用经过验证的商业仪器和软件测量房水的表面张力，该仪器和软件使用已知液体（去离子水和甲醇）进行了验证。对 20 只兔眼的房水和玻璃体样本进行分析表明，该系统可成功用于少量眼液。然后在兔模型中研究了青光眼药物对房水表面张力的影响。比较了 66 例青光眼患者和 53 例无青光眼但有白内障患者的房水。
兔房水的表面张力为 65.9±1.2；玻璃体为 60.6±2.6；平衡盐溶液为 70.7±0.9。噻吗洛尔和拉坦前列素均未改变兔模型房水的表面张力。人房水的平均表面张力为 63.33±4.0（青光眼眼）和 66.19±2.64（伴有白内障的非青光眼眼）（P=0.0001）。
验证了从少量房水中测量表面张力的技术。青光眼患者房水的表面张力小于白内障患者房水的表面张力。
