Tomita G, Araie M, Kitazawa Y, Tsukahara S
Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Eye (Lond). 2004 Oct;18(10):984-9. doi: 10.1038/sj.eye.6701373.
To compare the longitudinal effects of treatment on intraocular pressure (IOP) and visual field performance in Japanese normal-tension glaucoma (NTG) between latanoprost and timolol.
This is an open-label, randomized, study. A total of 62 NTG patients were prospectively, consecutively enrolled. All study subjects were randomly assigned to 0.005% latanoprost instillation once daily in the morning or 0.5% timolol instillation twice daily for a prospective 3-year follow-up, and underwent a routine ocular examination every month. Automated perimetry was performed every 6 months using Humphrey field analysers. Stereophotographs of optic discs were also obtained every 6 months.
Percentage of IOP reduction or the magnitude of IOP reduction showed no intergroup differences either at any time point (13-15%). In the visual field, the estimated rate of change in the MD value (dB/year) was -0.34+/-0.17 (SE) for the latanoprost group, and -0.10+/-0.18 (SE) for the timolol group. The estimated rate of change in MD showed no significant difference from zero in both groups, and there were no statistical intergroup differences. No changes in the optic nerve head topography in the vertical cup-to-disc ratio and rim area measured by image-analysis techniques were observed in either group. There were no patients who dropped out due to the side effects of treatment regimens.
Both latanoprost and timolol single treatments reduced IOP by 13-15% at their trough effects for 3 years in Japanese NTG patients; both showed similar effects on visual field performance.
比较拉坦前列素和噻吗洛尔对日本正常眼压性青光眼（NTG）患者眼压（IOP）和视野的长期治疗效果。
这是一项开放标签的随机研究。共有62例NTG患者前瞻性地连续入组。所有研究对象被随机分配为每天早晨一次滴注0.005%拉坦前列素或每天两次滴注0.5%噻吗洛尔，进行为期3年的前瞻性随访，每月进行一次常规眼部检查。每6个月使用Humphrey视野分析仪进行自动视野检查。每6个月还获取视盘的立体照片。
在任何时间点，IOP降低的百分比或IOP降低的幅度均无组间差异（13 - 15%）。在视野方面，拉坦前列素组平均缺损（MD）值的估计变化率（dB/年）为 -0.34 ± 0.17（标准误），噻吗洛尔组为 -0.10 ± 0.18（标准误）。两组MD的估计变化率与零均无显著差异，且组间无统计学差异。两组通过图像分析技术测量的垂直杯盘比和边缘面积的视神经乳头形态均未观察到变化。没有患者因治疗方案的副作用而退出。
在日本NTG患者中，拉坦前列素和噻吗洛尔单一治疗在3年的最低效应时均可使IOP降低13 - 15%；两者对视野的影响相似。
