Arkwright John W, Underhill Ian D, Maunder Simon A, Blenman Neil, Szczesniak Michal M, Wiklendt Lukasz, Cook Ian J, Lubowski David Z, Dinning Phil G
CSIRO Materials Science and Engineering, PO Box 218, Lindfield, NSW 2070, Australia.
Opt Express. 2009 Dec 7;17(25):22423-31. doi: 10.1364/OE.17.022423.
The design of a fibre Bragg grating based manometry catheter for in-vivo diagnostics in the human colon is presented. The design is based on a device initially developed for use in the oesophagus, but in this instance, longer sensing lengths and increased flexibility were required to facilitate colonoscopic placement of the device and to allow access to the convoluted regions of this complex organ. The catheter design adopted allows the number of sensing regions to be increased to cover extended lengths of the colon whilst maintaining high flexibility and the close axial spacing necessary to accurately record pertinent features of peristalsis. Catheters with 72 sensing regions with an axial spacing of 1 cm have been assembled and used in-vivo to record peristaltic contractions in the human colon over a 24hr period. The close axial spacing of the pressure sensors has, for the first time, identified the complex nature of propagating sequences in both antegrade (towards the anus) and retrograde (away from the anus) directions in the colon. The potential to miss propagating sequences at wider sensor spacings is discussed and the resultant need for close axial spacing of sensors is proposed.
介绍了一种基于光纤布拉格光栅的测压导管的设计，用于人体结肠的体内诊断。该设计基于最初开发用于食管的一种装置，但在这种情况下，需要更长的传感长度和更高的灵活性，以方便该装置在结肠镜检查时放置，并能进入这个复杂器官的曲折区域。所采用的导管设计允许增加传感区域的数量，以覆盖结肠的更长长度，同时保持高灵活性以及准确记录蠕动相关特征所需的紧密轴向间距。已组装了具有72个传感区域、轴向间距为1厘米的导管，并在体内用于记录人体结肠24小时内的蠕动收缩情况。压力传感器紧密的轴向间距首次确定了结肠中顺行（向肛门方向）和逆行（远离肛门方向）传播序列的复杂性质。讨论了在传感器间距较宽时错过传播序列的可能性，并提出了传感器紧密轴向间距的必要性。
