Departments of Gastroenterology & Surgery, Flinders Medical Centre, Flinders University, South Australia, Australia; School of Medicine, University of New South Wales, New South Wales, Australia.
Neurogastroenterol Motil. 2013 Oct;25(10):e640-9. doi: 10.1111/nmo.12170. Epub 2013 Jun 17.
High-resolution manometry catheters are now being used to record colonic motility. The aim of this study was to determine the influence of pressure sensor spacing on our ability to identify colonic propagating sequences (PS).
Fiber-optic catheters containing 72-90 sensors spaced at 1 cm intervals were placed colonoscopically to the cecum in 11 patients with proven slow transit constipation, 11 patients with neurogenic fecal incontinence and nine healthy subjects. A 2 h section of trace from each subject was analyzed. Using the 1 cm spaced data as the gold standard, each data set was then sub-sampled, by dropping channels from the data set to simulate sensor spacing of 10, 7, 5, 3, and 2 cm. In blinded fashion, antegrade and retrograde PS were quantified at each test sensor spacing. The data were compared to the PSs identified in the corresponding gold standard data set.
In all subject groups as sensor spacing increased; (i) the frequency of identified antegrade and retrograde PSs decreased (P < 0.0001); (ii) the ratio of antegrade to retrograde PSs increased (P < 0.0001); and (iii) the number of incorrectly labeled PSs increased (P < 0.003).
CONCLUSIONS & INFERENCES: Doubling the sensor spacing from 1 to 2 cm nearly halves the number of PSs detected. Tripling the sensor spacing from 1 to 3 cm resulted in a 30% chance of incorrectly labeling PSs. Closely spaced pressure recording sites (<2 cm) are mandatory to avoid gross misrepresentation of the frequency, morphology, and directionality of colonic propagating sequences.
高分辨率测压导管现在用于记录结肠动力。本研究的目的是确定压力传感器间距对我们识别结肠传播序列（PS）的能力的影响。
将包含 72-90 个传感器的光纤导管以 1cm 的间隔间隔放置在结肠镜检查到的 11 例证实的慢传输性便秘、11 例神经源性粪便失禁和 9 例健康受试者的盲肠中。分析每个受试者 2 小时的迹线部分。使用 1cm 间隔的数据作为金标准，然后通过从数据集中删除通道来对每个数据集进行子采样，以模拟传感器间隔为 10、7、5、3 和 2cm。以盲法方式在每个测试传感器间隔量化顺行和逆行 PS。将数据与相应金标准数据集中识别的 PS 进行比较。
在所有受试者组中，随着传感器间距的增加；（i）识别出的顺行和逆行 PS 的频率降低（P<0.0001）；（ii）顺行与逆行 PS 的比例增加（P<0.0001）；和（iii）错误标记的 PS 数量增加（P<0.003）。
将传感器间距从 1 增加到 2cm 几乎将检测到的 PS 数量减少了一半。将传感器间距从 1 增加到 3cm 会导致 30%的 PS 错误标记的机会。紧密间隔的压力记录位点（<2cm）是避免对结肠传播序列的频率、形态和方向性产生严重误解的必要条件。
