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检测幽门螺杆菌 cagA 基因 3' 重复区的地理、临床和宿主内变异。

Examination of geographical, clinical and intrahost variations in the 3' repeat region of cagA gene in Helicobacter pylori.

机构信息

Department of Gastroenterology, Kyungpook National University, Daegu, Korea.

出版信息

J Korean Med Sci. 2010 Jan;25(1):61-6. doi: 10.3346/jkms.2010.25.1.61. Epub 2009 Dec 26.

DOI:10.3346/jkms.2010.25.1.61
PMID:20052349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2800007/
Abstract

The size variation of the cytoxin-associated protein (cagA), which is dependent on the 3' repeat region (3'RR) of the cagA gene, is known to play a crucial role in the pathogenesis of Helicobacter pylori infection. The present study evaluated the relationship between the 3'RR variation and the geographic distribution, clinical manifestations, and locations of colonization in the stomach. We evaluated the 3'RR of H. pylori isolates from 78 patients with gastric cancer, peptic ulcer, and non-ulcer dyspepsia from Japan, Hong Kong, India, and the United States and assessed the variations of 3'RR according to the geographical and clinical characteristics. Sixty eight (87.2%) patients had the same 650 bp band without geographical differences. The frequency of polymorphisms in the 3'RR did not differ when compared to the clinical manifestations (P=0.868). The length of 3'RR did not differ by location of colonization. In conclusion, the 3'RR variation of cagA gene is not associated with the geographical and clinical characteristics of the patients studied.

摘要

细胞毒素相关蛋白（cagA）的大小变异与 cagA 基因的 3'重复区（3'RR）有关，已知其在幽门螺杆菌感染的发病机制中起着关键作用。本研究评估了 3'RR 变异与地理分布、临床表现和胃部定植部位之间的关系。我们评估了来自日本、中国香港、印度和美国的 78 例胃癌、消化性溃疡和非溃疡性消化不良患者的幽门螺杆菌分离株的 3'RR，并根据地理和临床特征评估了 3'RR 的变异情况。68 例（87.2%）患者具有相同的 650 bp 带，没有地理差异。3'RR 多态性的频率与临床表现相比没有差异（P=0.868）。定植部位的 3'RR 长度没有差异。总之，cagA 基因 3'RR 的变异与所研究患者的地理和临床特征无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/665c/2800007/84869e879d94/jkms-25-61-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/665c/2800007/f3913831b2d5/jkms-25-61-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/665c/2800007/cd9187722901/jkms-25-61-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/665c/2800007/9b0aa69940ea/jkms-25-61-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/665c/2800007/33f6298e49c5/jkms-25-61-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/665c/2800007/84869e879d94/jkms-25-61-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/665c/2800007/f3913831b2d5/jkms-25-61-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/665c/2800007/cd9187722901/jkms-25-61-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/665c/2800007/9b0aa69940ea/jkms-25-61-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/665c/2800007/33f6298e49c5/jkms-25-61-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/665c/2800007/84869e879d94/jkms-25-61-g005.jpg

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本文引用的文献

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The relationship between virulence factors of Helicobacter pylori and severity of gastritis in infected patients.幽门螺杆菌毒力因子与感染患者胃炎严重程度之间的关系。
Dig Dis Sci. 2009 Jan;54(1):103-10. doi: 10.1007/s10620-008-0316-9. Epub 2008 May 9.
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Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age.幽门螺杆菌毒力基因型vacA和cagA与胃炎组织学参数及患者年龄的相关性
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Analysis of the 3' variable region of the cagA gene of Helicobacter pylori isolated in Koreans.
对从韩国人分离出的幽门螺杆菌cagA基因3'可变区的分析。
Dig Dis Sci. 2007 Apr;52(4):960-6. doi: 10.1007/s10620-005-9030-z. Epub 2007 Mar 7.
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cagA genotype and variants in Chinese Helicobacter pylori strains and relationship to gastroduodenal diseases.中国幽门螺杆菌菌株中cagA基因型及变异体与胃十二指肠疾病的关系
J Med Microbiol. 2004 Mar;53(Pt 3):231-235. doi: 10.1099/jmm.0.05366-0.
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The size of cagA based on repeat sequence has the responsibility of the location of Helicobacter pylori in the gastric mucus and the degree of gastric mucosal inflammation.
Microbiol Immunol. 2003;47(9):619-30. doi: 10.1111/j.1348-0421.2003.tb03425.x.
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Histological and clinical predictive value of determination of tissue CagA status by PCR in Helicobacter pylori infected patients; results of the large population based study in western Turkey.通过聚合酶链反应（PCR）测定组织中CagA状态对幽门螺杆菌感染患者的组织学和临床预测价值；土耳其西部基于大量人群的研究结果
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Geographic differences and the role of cagA gene in gastroduodenal diseases associated with Helicobacter pylori infection.地理差异以及cagA基因在幽门螺杆菌感染相关胃十二指肠疾病中的作用。
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Heterogeneity in the Helicobacter pylori vacA and cagA genes: association with gastroduodenal disease in South Africa?幽门螺杆菌vacA和cagA基因的异质性：与南非胃十二指肠疾病的关联？
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