Center for Instrumental Analysis, China Pharmaceutical University (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education), Nanjing, 210009, China.
Anal Bioanal Chem. 2010 Mar;396(5):1921-7. doi: 10.1007/s00216-009-3350-3. Epub 2010 Jan 6.
Traditional bistable stochastic resonance has been demonstrated as an effective tool to detect the weak signal in a strong noise background. To achieve a better signal-to-noise ratio for the output signal, a coupled stochastic resonance was developed by nonlinearly coupling two double-well potential systems. The response characteristics of coupled stochastic resonance subjected to analytical signals have been investigated and compared with those of bistable stochastic resonance. The improvement of chromatographic determination with the proposed coupled stochastic resonance was validated by both simulated signals and chromatographic signals. The weak signals from both simulated data and plasma samples with different concentrations were all amplified significantly and the quantitative relationship between different concentrations and responses was kept well. It is reasonable to believe that coupled stochastic resonance could play an important role in applications where quantitative determination of low-concentration samples is crucial.
传统的双稳随机共振已被证明是一种有效的工具，可以在强噪声背景下检测弱信号。为了使输出信号的信噪比更好，通过非线性耦合两个双势阱系统，开发了一种耦合随机共振。本文研究了受解析信号作用的耦合随机共振的响应特性，并与双稳随机共振进行了比较。通过模拟信号和色谱信号验证了所提出的耦合随机共振对色谱测定的改进。来自模拟数据和不同浓度血浆样本的弱信号都得到了显著放大，不同浓度与响应之间的定量关系保持良好。可以合理地认为，在定量测定低浓度样品至关重要的应用中，耦合随机共振可能会发挥重要作用。
