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[传统准分子激光原位角膜磨镶术后的对比敏感度和高阶像差]

[Contrast sensitivity and higher order aberration after conventional LASIK treatment].

作者信息

Loukotová V, Vlková E, Horácková M, Tokosová E, Pirnerová L, Hlinomazová Z, Dvoráková D, Nĕmec J

机构信息

Ocní klinika LF MU, FN Brno.

出版信息

Cesk Slov Oftalmol. 2009 Oct;65(5):167-75.

PMID:20052819
Abstract

AIM

The aim of the prospective study was to evaluate photopic high-contrast visual acuity, mesopic contrast sensitivity, and high order aberrations, to compare changes and post-operative development of those parameters and to analyze the dependence among aberrations and contrast sensitivity after conventional LASIK treatment.

MATERIALS AND METHODS

The authors followed-up patients treated by means of refractive LASIK treatment during the period from November 2006 to November 2007. The authors analyzed 51 eyes (31 patients). The average age of the group was 28.5 +/- 5.4 years (range, 18 - 41 years), preoperative average spherical equivalent was -4.95 +/- 1.24 D (from -3 to -8,25 D). Before the treatment and 1, 3, 6, and 12 months after LASIK treatment we evaluated the visual acuity (Snellen optotypes), contrast sensitivity under mesopic circumstances (CSV-1000E, VectorVision) and monochromatic aberrations (aberometer Zywave, Bausch & Lomb).

RESULTS

One year after the treatment the average uncorrected visual acuity was 1.07 +/- 0.15, index of effectiveness 0.99, and index of safety 1.02. The contrast sensitivity was in month 12 significantly decreased comparing to the preoperative level at the frequency 12 c/deg, in other already tested frequencies after 3-6 moths did not differed from preoperative values. During the follow-up period the curvature of contrast sensitivity average values was in the upper half of the normal interval range. Conventional LASIK treatment significantly induced the higher order aberration (twice), as well as the spherical aberration (four times).The same level of higher order aberrations root mean square (HOA-RMS), or increased maximally by 0.1 microm was detected by 10 % of cases; the spherical aberration was, compared to the preoperative value, lower, or increased maximally by 0.05 microm in almost one half of the cases. The increase of the higher order aberrations depended directly proportionally to the preoperative value of the spherical equivalent. Before the treatment, the values of total aberrations correlated to the contrast sensitivity of low space frequencies; however, there was not found any correlation between the higher order aberrations and contrast sensitivity. Six months after the LASIK treatment the values of higher order aberrations correlated to the contrast sensitivity except of the lowest frequency tested. The higher order aberrations increased together with decreasing contrast sensitivity. The data from the one-year follow up control did not show statistically significant correlation between the contrast sensitivity and the higher order aberrations. There was not found any correlation between the contrast sensitivity and the spherical aberration at any follow-up control after the surgery.

CONCLUSION

Although after the conventional LASIK treatment the curve of mesopic contrast sensitivity was located in the upper half of the normal range, in the medial space frequency it remained decreased comparing to the preoperative stage. The induction of higher order aberrations was twice as much and was directly correlated to the degree of the laser correction. The spherical aberration was four-times higher comparing to the preoperative values and was independent to the level of the initial refractive error. Significant correlation between the contrast sensitivity and the higher order aberrations was not proven.

摘要

目的

本前瞻性研究旨在评估明视高对比度视力、中间视觉对比度敏感度和高阶像差,比较这些参数的变化及术后发展情况,并分析传统准分子激光原位角膜磨镶术(LASIK)治疗后像差与对比度敏感度之间的相关性。

材料与方法

作者对2006年11月至2007年11月期间接受屈光性LASIK治疗的患者进行随访。分析了51只眼(31例患者)。该组患者的平均年龄为28.5±5.4岁(范围18 - 41岁),术前平均等效球镜度为-4.95±1.24 D(-3至-8.25 D)。在LASIK治疗前及治疗后1、3、6和12个月,我们评估了视力(Snellen视力表)、中间视觉环境下的对比度敏感度(CSV - 1000E,VectorVision)和单色像差(像差仪Zywave,博士伦)。

结果

治疗1年后,平均裸眼视力为1.07±0.15,有效性指数为0.99,安全性指数为1.02。在12个月时,与术前水平相比,12 c/deg频率下的对比度敏感度显著降低,在其他已测试频率下,3 - 6个月后与术前值无差异。在随访期间,对比度敏感度平均值的曲线处于正常区间范围的上半部分。传统LASIK治疗显著诱导了高阶像差(两倍)以及球差(四倍)。10%的病例检测到相同水平的高阶像差均方根(HOA - RMS),或最大增加0.1微米;与术前值相比,几乎一半的病例球差更低,或最大增加0.05微米。高阶像差的增加与术前等效球镜度值直接成正比。治疗前,总像差值与低空间频率的对比度敏感度相关;然而,未发现高阶像差与对比度敏感度之间存在任何相关性。LASIK治疗6个月后,除最低测试频率外,高阶像差值与对比度敏感度相关。高阶像差随着对比度敏感度的降低而增加。1年随访对照数据未显示对比度敏感度与高阶像差之间存在统计学显著相关性。术后任何随访对照中均未发现对比度敏感度与球差之间存在任何相关性。

结论

尽管传统LASIK治疗后中间视觉对比度敏感度曲线位于正常范围的上半部分,但在中间空间频率下与术前阶段相比仍有所降低。高阶像差的诱导量是原来的两倍,且与激光矫正程度直接相关。球差比术前值高四倍,且与初始屈光不正程度无关。未证实对比度敏感度与高阶像差之间存在显著相关性。

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