The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Int J Gynaecol Obstet. 2010 Mar;108(3):269-75. doi: 10.1016/j.ijgo.2009.12.001. Epub 2010 Jan 6.
This literature review compiles data on rates of use, indications, types of provider, mode of administration, and dose of uterotonics used for home births in low-income countries, and identifies gaps meriting further research.
Published and unpublished English language articles from 1995 through 2008 pertaining to home use of uterotonics were identified via electronic searches of medical and social science databases. In addition, bibliographies of articles were examined for eligible studies. Data were abstracted and analyzed by the objectives outlined for this review.
Twenty-three articles met the inclusion/exclusion criteria. Use rates of uterotonics at home births ranged widely from 1% to 69%, with the large majority of observations from South Asia. Descriptive studies suggest that home use of uterotonics before delivery of the baby are predominantly administered by nonprofessionals to accelerate labor, and are not perceived as unsafe.
To achieve maximum benefit and minimal harm, programs that increase access to uterotonics for postpartum hemorrhage prevention must take into account existing practices among pregnant women. Further research regarding access to uterotonics and intervention studies for provider behavior change regarding uterotonic use is warranted.
本文献综述汇总了低收入国家家庭分娩中缩宫素使用的使用率、适应证、提供者类型、给药方式和剂量的数据，并确定了需要进一步研究的空白点。
通过电子检索医学和社会科学数据库，从 1995 年至 2008 年期间检索到与家庭使用缩宫素相关的已发表和未发表的英文文章。此外，还查阅了文章的参考文献，以寻找符合条件的研究。根据本综述的目标，对数据进行了提取和分析。
有 23 篇文章符合纳入/排除标准。缩宫素在家中分娩的使用率差异很大，从 1%到 69%不等，其中大多数观察结果来自南亚。描述性研究表明，在分娩前在家中使用缩宫素主要是由非专业人员来加速分娩，而且被认为是安全的。
为了实现最大的益处和最小的伤害，增加产后出血预防用缩宫素的获取途径的项目必须考虑到孕妇现有的做法。需要进一步研究获取缩宫素的途径以及针对提供者使用缩宫素行为改变的干预研究。
