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New Evidence on Carbetocin: Another Arrow in Our Quiver.卡贝缩宫素新证据:我们箭袋中的又一利器。
Glob Health Sci Pract. 2018 Oct 4;6(3):405-407. doi: 10.9745/GHSP-D-18-00336. Print 2018 Oct 3.
2
The role of carbetocin in the prevention and management of postpartum haemorrhage.卡贝缩宫素在产后出血预防及处理中的作用
Int J Obstet Anesth. 2016 Dec;28:61-69. doi: 10.1016/j.ijoa.2016.10.003. Epub 2016 Oct 18.
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Carbetocin versus oxytocin for prevention of postpartum hemorrhage in patients with severe preeclampsia: a double-blind randomized controlled trial.卡贝缩宫素与缩宫素预防重度子痫前期患者产后出血的双盲随机对照试验。
J Obstet Gynaecol Can. 2011 Nov;33(11):1099-1104. doi: 10.1016/S1701-2163(16)35077-0.
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A prospective cohort study evaluating the cost-effectiveness of carbetocin for prevention of postpartum haemorrhage in caesarean sections.一项评估卡贝缩宫素预防剖宫产产后出血成本效益的前瞻性队列研究。
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[Carbetocin versus Oxytocin during caesarean section for preventing postpartum haemorrhage].
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Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial.卡贝缩宫素在剖宫产术后预防产后出血中的应用:一项随机临床试验。
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Carbetocin versus oxytocin for prevention of postpartum hemorrhage in obese nulliparous women undergoing emergency cesarean delivery.卡贝缩宫素与缩宫素用于预防肥胖初产妇急诊剖宫产术后出血的比较
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[Evaluation of carbetocin and oxytocin efficacy in prevention of postpartum hemorrhage in women after cesarean section].卡贝缩宫素与缩宫素预防剖宫产术后产妇产后出血的疗效评估
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本文引用的文献

1
Intramuscular versus intravenous oxytocin to prevent postpartum haemorrhage at vaginal delivery: randomised controlled trial.肌肉注射与静脉注射催产素预防阴道分娩产后出血:随机对照试验。
BMJ. 2018 Sep 4;362:k3546. doi: 10.1136/bmj.k3546.
2
Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth.卡贝缩宫素与缩宫素预防阴道分娩后出血的比较。
N Engl J Med. 2018 Aug 23;379(8):743-752. doi: 10.1056/NEJMoa1805489. Epub 2018 Jun 27.
3
Risk factors for stillbirths: how much can a responsive health system prevent?导致死产的风险因素:一个有响应能力的卫生系统能预防多少?
BMC Pregnancy Childbirth. 2018 Jan 18;18(1):33. doi: 10.1186/s12884-018-1660-1.
4
The role of carbetocin in the prevention and management of postpartum haemorrhage.卡贝缩宫素在产后出血预防及处理中的作用
Int J Obstet Anesth. 2016 Dec;28:61-69. doi: 10.1016/j.ijoa.2016.10.003. Epub 2016 Oct 18.
5
Perinatal mortality associated with use of uterotonics outside of Comprehensive Emergency Obstetric and Neonatal Care: a cross-sectional study.综合紧急产科和新生儿护理之外使用宫缩剂相关的围产期死亡率:一项横断面研究。
Reprod Health. 2016 Oct 6;13(1):129. doi: 10.1186/s12978-016-0241-x.
6
Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature.低收入和中等收入国家可获得的催产素质量:文献系统评价
BJOG. 2016 Dec;123(13):2076-2086. doi: 10.1111/1471-0528.13998. Epub 2016 Mar 22.
7
Accessibility and potency of uterotonic drugs purchased by simulated clients in four districts in India.印度四个地区模拟客户购买的宫缩剂的可及性和效力。
BMC Pregnancy Childbirth. 2014 Nov 13;14:386. doi: 10.1186/s12884-014-0386-y.
8
Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage.用于分娩第三产程的预防性缩宫素以预防产后出血。
Cochrane Database Syst Rev. 2013 Oct 30(10):CD001808. doi: 10.1002/14651858.CD001808.pub2.
9
Injections during labor and intrapartum-related hypoxic injury and mortality in rural southern Nepal.尼泊尔南部农村地区分娩期间的注射与产时相关缺氧损伤和死亡。
Int J Gynaecol Obstet. 2013 Jul;122(1):22-6. doi: 10.1016/j.ijgo.2013.02.013. Epub 2013 Mar 21.
10
Uterotonic drug quality: an assessment of the potency of injectable uterotonic drugs purchased by simulated clients in three districts in Ghana.宫缩剂药物质量:对加纳三个地区模拟客户购买的注射用宫缩剂药物效力的评估。
BMJ Open. 2012 May 3;2(3). doi: 10.1136/bmjopen-2011-000431. Print 2012.

卡贝缩宫素新证据:我们箭袋中的又一利器。

New Evidence on Carbetocin: Another Arrow in Our Quiver.

机构信息

Editor-in-Chief, Global Health: Science and Practice Journal, and Associate Professor, School of Public Health, University of Alberta, Edmonton, Alberta, Canada.

出版信息

Glob Health Sci Pract. 2018 Oct 4;6(3):405-407. doi: 10.9745/GHSP-D-18-00336. Print 2018 Oct 3.

DOI:10.9745/GHSP-D-18-00336
PMID:30287526
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6172116/
Abstract

Carbetocin is more heat stable than oxytocin with at least equivalent efficacy for preventing postpartum hemorrhage. It will certainly be helpful if the supplier can make it available in low-income country settings at a price comparable to oxytocin. But even so, programs will still need oxytocin and other uterotonic medications.

摘要

卡贝缩宫素比催产素更热稳定,对于预防产后出血至少具有同等疗效。如果供应商能够以与催产素相当的价格在低收入国家提供这种药物,那将是非常有帮助的。但即便如此,项目仍将需要催产素和其他子宫收缩药物。