Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
J Surg Res. 2010 Aug;162(2):239-49. doi: 10.1016/j.jss.2009.06.021. Epub 2009 Jul 17.
Over the past century, numerous animal models have been developed in an attempt to understand myocardial and vascular injury. However, the successful translation of results observed in animals to human therapy remains low. To understand this problem, we present several animal models of cardiac and vascular injury that are of particular relevance to the cardiac or vascular surgeon. We also explore the potential clinical implications and limitations of each model with respect to the human disease state. Our results underscore the concept that animal research requires an in-depth understanding of the model, animal physiology, and the potential confounding factors. Future outcome analyses with standardized animal models may improve translation of animal research from the bench to the bedside.
在过去的一个世纪中，人们开发了许多动物模型，试图了解心肌和血管损伤。然而，将在动物身上观察到的结果成功转化为人类治疗仍然很低。为了解决这个问题，我们介绍了几种与心脏或血管外科医生特别相关的心脏和血管损伤的动物模型。我们还探讨了每个模型对人类疾病状态的潜在临床意义和局限性。我们的研究结果强调了一个概念，即动物研究需要深入了解模型、动物生理学以及潜在的混杂因素。未来使用标准化动物模型进行的结果分析可能会提高从实验室到临床的动物研究的转化。
