Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC.
Environ Pollut. 2010 May;158(5):1494-505. doi: 10.1016/j.envpol.2009.12.021. Epub 2010 Jan 6.
The purpose of this paper was to use quantitative systems-level approach employing biotic ligand model based threshold damage model to examine physiological responses of tilapia and freshwater clam to sequential pulsed and fluctuating arsenic concentrations. We tested present model and triggering mechanisms by carrying out a series of modeling experiments where we used periodic pulses and sine-wave as featured exposures. Our results indicate that changes in the dominant frequencies and pulse timing can shift the safe rate distributions for tilapia, but not for that of freshwater clam. We found that tilapia increase bioenergetic costs to maintain the acclimation during pulsed and sine-wave exposures. Our ability to predict the consequences of physiological variation under time-varying exposure patterns has also implications for optimizing species growing, cultivation strategies, and risk assessment in realistic situations.
本文旨在采用定量系统水平方法，利用基于生物配体模型的阈值损伤模型，研究罗非鱼和淡水贻贝对连续脉冲和波动砷浓度的生理反应。我们通过进行一系列建模实验来测试现有模型和触发机制，其中我们使用周期性脉冲和正弦波作为特征暴露。我们的结果表明，主导频率和脉冲定时的变化可以改变罗非鱼的安全率分布，但对淡水贻贝没有影响。我们发现，罗非鱼在脉冲和正弦波暴露期间增加了生物能量成本来维持适应。我们预测在时变暴露模式下生理变化后果的能力也对优化现实情况下的物种生长、养殖策略和风险评估具有重要意义。
