Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama 230-0045, Japan.
Int Immunol. 2010 Feb;22(2):65-70. doi: 10.1093/intimm/dxp125. Epub 2010 Jan 6.
Blood cells comprise very diverse cell types with a wide range of crucial functions; however, they share a common progenitor cell type-the hematopoietic stem cell (HSC). Clarifying how HSCs differentiate into these diverse cell types is important for understanding how they attain their various functions and offers the potential for therapeutic manipulation. Various theories exist about how HSCs diversify; in particular, one model (the 'classical' model) proposes that lymphocytes and myelo-erythroid lineages branch separately at an early stage of hematopoiesis, whereas another model (the 'myeloid-based' model) proposes that the myeloid potential is retained for much longer among cells that can become lymphocytes. This article describes and compares these models and outlines recent evidence supporting the myeloid-based model.
血细胞包含非常多样化的细胞类型，具有广泛的关键功能；然而，它们都具有一个共同的祖细胞类型——造血干细胞（HSC）。阐明 HSC 如何分化为这些不同的细胞类型对于理解它们如何获得各种功能很重要，并且为治疗性干预提供了潜力。关于 HSC 如何多样化存在各种理论；特别是，一个模型（“经典”模型）提出淋巴细胞和髓系-红细胞谱系在造血的早期阶段分别分支，而另一个模型（“基于髓系”模型）提出在可以成为淋巴细胞的细胞中，髓系潜能保留得更久。本文描述并比较了这些模型，并概述了支持基于髓系模型的最新证据。
