Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, SE-171 76 Stockholm, Sweden.
Haematologica. 2010 Jul;95(7):1216-20. doi: 10.3324/haematol.2009.020412. Epub 2010 Jan 6.
The causes of myeloproliferative neoplasm (MPN) are unknown. We conducted a large population-based study including 11,039 myeloproliferative neoplasm patients and 43,550 matched controls with the aim of assessing the associations between a personal history of a broad span of autoimmune diseases and subsequent risk of myeloproliferative neoplasm. We found a prior history of any autoimmune disease to be associated with a significantly increased risk of myeloproliferative neoplasms (odds ratio (OR)=1.2; 95% confidence interval (CI) 1.0-1.3; P=0.021). Specifically, we found an increased risk of MPNs associated with a prior immune thrombocytopenic purpura (2.9; 1.7-7.2), Crohn's disease (1.8; 1.1-3.0), polymyalgia rheumatica (1.7; 1.2-2.5), giant cell arteritis (5.9; 2.4-14.4), Reiter's syndrome (15.9; 1.8-142) and aplastic anemia (7.8; 3.7-16.7). The risk of myeloproliferative neoplasms associated with prior autoimmune diseases is modest but statistically significant. Future studies are needed to unravel the effects of these autoimmune diseases themselves, their treatment, or common genetic susceptibility.
骨髓增殖性肿瘤（MPN）的病因尚不清楚。我们进行了一项大型基于人群的研究，纳入了 11039 名 MPN 患者和 43550 名匹配对照，旨在评估广泛的自身免疫性疾病病史与随后发生 MPN 的风险之间的关联。我们发现，任何自身免疫性疾病病史与 MPN 的发生风险显著增加相关（比值比（OR）=1.2；95%置信区间（CI）1.0-1.3；P=0.021）。具体而言，我们发现既往免疫性血小板减少性紫癜（2.9；1.7-7.2）、克罗恩病（1.8；1.1-3.0）、巨细胞动脉炎（5.9；2.4-14.4）、风湿性多肌痛（1.7；1.2-2.5）、Reiter 综合征（15.9；1.8-142）和再生障碍性贫血（7.8；3.7-16.7）与 MPN 发生风险增加相关。与既往自身免疫性疾病相关的 MPN 发生风险虽然适度，但具有统计学意义。需要进一步的研究来阐明这些自身免疫性疾病本身、它们的治疗或共同的遗传易感性的影响。
