葡萄糖-6-磷酸脱氢酶缺乏症儿科患者溶血性危象诱发因素的审核。
An audit of the precipitating factors for haemolytic crisis among glucose-6-phosphate dehydrogenase-deficient paediatric patients.
机构信息
Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.
出版信息
J Med Screen. 2009;16(4):167-9. doi: 10.1258/jms.2009.009066.
BACKGROUND
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common genetic enzyme deficiencies leading to haemolytic anaemia. This study aimed to investigate the precipitating factors for haemolytic crisis in G6PD-deficient paediatric patients in Jordan.
METHOD
A retrospective study of data from the records of 258 paediatric patients admitted to a major paediatric hospital in North Jordan from January 2001 until April 2007. Patients included were G6PD-deficient children who were admitted to the hospital secondary to an episode of haemolytic anaemia.
RESULTS
Of 258 paediatric patients, 244 (94.2%) had developed a haemolytic episode secondary to ingestion of fava beans. The remaining 14 children (5.8%) developed a haemolytic episode triggered by other factors, such as drugs and upper respiratory infections.
CONCLUSION
Fava bean ingestion is the major precipitating factor for haemolytic anaemia episodes among G6PD-deficient children in Jordan.
背景
葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症是导致溶血性贫血的最常见遗传酶缺乏症之一。本研究旨在调查约旦 G6PD 缺乏症儿科患者溶血性危象的诱发因素。
方法
对 2001 年 1 月至 2007 年 4 月在约旦北部一家主要儿科医院住院的 258 例儿科患者的病历数据进行回顾性研究。纳入的患者为因溶血性贫血发作而入院的 G6PD 缺乏症儿童。
结果
在 258 例儿科患者中，244 例（94.2%）因食用蚕豆而发生溶血性发作。其余 14 名儿童（5.8%）因其他因素如药物和上呼吸道感染而发生溶血性发作。
结论
蚕豆摄入是约旦 G6PD 缺乏症儿童溶血性贫血发作的主要诱发因素。
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