Department of Biochemistry, International Centre for Cardio Thoracic and Vascular Diseases, A Unit of Frontier Lifeline, Dr KM Cherian Heart Foundation, Chennai, Tamil Nadu, India.
J Hum Hypertens. 2010 Jul;24(7):475-82. doi: 10.1038/jhh.2009.100. Epub 2010 Jan 7.
To investigate the total antioxidant status (TAS) and the extent of oxidative DNA damage in total lymphocytes and their relation with essential hypertension. A total of 130 South Indian subjects aged 30-65 were recruited for the study. Of these hypertensive subjects investigated, 30 were newly diagnosed and were not on any antihypertensive drugs, but had systolic blood pressure (BP) ranging between 140 and 160 mm Hg and diastolic BP between 95 and 100 mm Hg; 50 hypertensive patients who were already on drug therapy for 1 year and 50 were normotensive controls with BP < or =120/80 mm Hg. DNA damage was significantly increased in hypertensive patients (both newly diagnosed and who were already on drug therapy) compared with control group. The major increase in DNA damage was observed in newly diagnosed hypertensive patients compared with hypertensive patients who were already on drug therapy. There was a significant decrease in plasma TAS value in essential hypertensive groups as compared to normotensive controls. Lymphocyte DNA damage was independently correlated with only TAS. Lymphocyte DNA damage was increased in hypertensive patients. The major increase in lymphocyte DNA damage was observed in newly diagnosed hypertensive patients compared with hypertensive patients who already on drug therapy. Decreased TAS levels, which reflect to increased oxidative stress, may be the reason of increased total lymphocyte DNA damage in South Indian hypertensive patients.
为了研究总抗氧化状态（TAS）和总淋巴细胞中氧化 DNA 损伤的程度及其与原发性高血压的关系。共招募了 130 名年龄在 30-65 岁的南印度受试者进行研究。在所调查的高血压受试者中，有 30 名是新诊断的，未服用任何降压药物，但收缩压（BP）在 140-160mmHg 之间，舒张压在 95-100mmHg 之间；50 名高血压患者已经接受了 1 年的药物治疗，50 名血压<或=120/80mmHg 的血压正常对照组。与对照组相比，高血压患者（新诊断和已接受药物治疗的患者）的 DNA 损伤明显增加。与已接受药物治疗的高血压患者相比，新诊断的高血压患者的 DNA 损伤增加幅度更大。与血压正常对照组相比，原发性高血压组的血浆 TAS 值显著降低。淋巴细胞 DNA 损伤与 TAS 呈独立相关。高血压患者的淋巴细胞 DNA 损伤增加。与已接受药物治疗的高血压患者相比，新诊断的高血压患者的淋巴细胞 DNA 损伤增加幅度更大。TAS 水平降低，反映氧化应激增加，可能是南印度高血压患者总淋巴细胞 DNA 损伤增加的原因。
