Department of Natural Sciences, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.
Korean J Physiol Pharmacol. 2009 Dec;13(6):469-73. doi: 10.4196/kjpp.2009.13.6.469. Epub 2009 Dec 31.
Induced activation of the gamma-aminobutyric acid(A) (GABA(A)) receptor in the retina of goldfish caused the fish to rotate in the opposite direction to that of the spinning pattern during an optomotor response (OMR) measurement. Muscimol, a GABA(A) receptor agonist, modified OMR in a concentration-dependent manner. The GABA(B) receptor agonist baclofen and GABA(C) receptor agonist CACA did not affect OMR. The observed modifications in OMR included decreased anterograde rotation (0.010.03 microM), coexistence of retrograde rotation and decreased anterograde rotation (0.130 microM) and only retrograde rotation (100 microM~1 mM). In contrast, the GABA(A) receptor antagonist bicuculline blocked muscimolinduced retrograde rotation. Based on these results, we inferred that the coding inducing retrograde movement of the goldfish retina is essentially associated with the GABA(A) receptor-related visual pathway. Furthermore, from our novel approach using observations of goldfish behavior the induced discrete snapshot duration was approximately 573 ms when the fish were under the influence of muscimol.
在金鱼的视网膜中诱导激活γ-氨基丁酸（A）（GABA(A)) 受体，会导致鱼在光反应（OMR）测量期间旋转方向与旋转模式相反。GABA(A) 受体激动剂 muscimol 以浓度依赖的方式修饰 OMR。GABA(B) 受体激动剂 baclofen 和 GABA(C) 受体激动剂 CACA 对 OMR 没有影响。观察到的 OMR 修饰包括前向旋转减少（0.010.03 microM）、逆行旋转和前向旋转减少共存（0.130 microM）以及仅逆行旋转（100 microM~1 mM）。相反，GABA(A) 受体拮抗剂 bicuculline 阻断了 muscimol 诱导的逆行旋转。基于这些结果，我们推断金鱼视网膜诱导逆行运动的编码与 GABA(A) 受体相关的视觉途径密切相关。此外，我们采用观察金鱼行为的新方法，当鱼受到 muscimol 影响时，诱导的离散快照持续时间约为 573 ms。
