Białecka Monika, Adamiak Urszula, Gawrońska-Szklarz Barbara
Zakład Farmakologii Doświadczalnej i Klinicznej, Katedra Farmakologii, Pomorska Akademia Medyczna w Szczecinie, Szczecin.
Neurol Neurochir Pol. 2009 Sep-Oct;43(5):446-59.
This article presents the major strategies for individualisation and optimisation of levodopa therapy. The relationship between pharmacokinetic and pharmacodynamic effects of levodopa is discussed. Pharmacokinetic parameters in different stages of Parkinson's disease are interpreted. Moreover, the main differences in pharmacokinetics of levodopa formulations and routes of administration are presented. The authors also suggest methods to increase efficacy and safety of levodopa therapy in patients with Parkinson's disease.
本文介绍了左旋多巴治疗个体化和优化的主要策略。讨论了左旋多巴的药代动力学和药效学效应之间的关系。解读了帕金森病不同阶段的药代动力学参数。此外，还介绍了左旋多巴制剂的药代动力学和给药途径的主要差异。作者还提出了提高帕金森病患者左旋多巴治疗疗效和安全性的方法。
