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[Churg-Strauss综合征病程中的多发性单神经病——病例报告]

[Multiple mononeuropathy in the course of the Churg-Strauss syndrome--a case study].

作者信息

Kubicka Katarzyna, Pierzchała Krystyna, Mańka-Gaca Iwona, Biernawska Jolanta, Mucha-Mazurkiewicz Anna

机构信息

Oddział Neurologii, Samodzielny Szpital Kliniczny, Zabrze.

出版信息

Neurol Neurochir Pol. 2009 Sep-Oct;43(5):484-9.

Abstract

The Churg-Strauss syndrome (CSS) is a systemic vasculitis. The symptoms of CSS normally occur between the ages of 20 and 40. We present a case of a 60-year-old man with the CSS evolving in three phases. The initial symptoms included bronchial asthma and inflammation of the ethmoid sinuses. Later, the patient was diagnosed with peripheral blood eosinophilia, pulmonary changes, skin changes and neurological symptoms that progressed to multiple mononeuropathy. Electrophysiological tests confirmed progressive damage of the peripheral nervous system. An improvement of the patient's neurological state was observed after application of corticosteroids and rehabilitation. CSS is one of the causes of multiple mononeuropathy and should be taken into account in differential diagnosis. In patients with bronchial asthma, hypereosinophilia and progressive damage of many nerves, the syndrome is diagnosed in accordance with the criteria defined by the American College of Rheumatology.

摘要

变应性肉芽肿性血管炎(CSS)是一种系统性血管炎。CSS的症状通常出现在20至40岁之间。我们报告一例60岁男性CSS患者,其病程发展分为三个阶段。初始症状包括支气管哮喘和筛窦炎症。后来,患者被诊断为外周血嗜酸性粒细胞增多、肺部改变、皮肤改变以及进展为多发性单神经病的神经症状。电生理检查证实了外周神经系统的进行性损害。应用糖皮质激素和康复治疗后,患者的神经状态有所改善。CSS是多发性单神经病病因之一,在鉴别诊断中应予以考虑。对于患有支气管哮喘、嗜酸性粒细胞增多和多根神经进行性损害的患者,根据美国风湿病学会定义的标准诊断该综合征。

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