两种头孢菌素对结肠细菌活性的微量热法研究
[Microcalorimetric investigation of two cephalosporins on colon bacteria activity].
作者信息
Xu Fen, Song Cheng-Gong, Wu Rui-Hua, Yang Li-Ni, Sun Li-Xian, Zhao Zong-Bao, Zhang Zhi-Heng, Cao Zhong, Zhang Ling
机构信息
College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
出版信息
Yao Xue Xue Bao. 2009 Oct;44(10):1127-30.
The effects of cephradinum and ceftazidime on the metabolism of Escherichia coli (E. coli) DH5alpha was determined by microcalorimetry. The microbial activity was recorded as power-time curves through an ampoule method with a TAM Air Isothermal Microcalorimeter at 37 degrees C. The parameters such as the growth rate constant (k), inhibitory ratio (I), the maximum power output (Pm) and the time (tm) corresponding to the maximum power output were calculated. The results show that the ceftazidime has a better inhibitory effect on E. coli DH5alpha than cephradinum.
采用微量量热法测定头孢拉定和头孢他啶对大肠杆菌（E. coli）DH5α代谢的影响。通过安瓿法，使用TAM Air等温微量量热仪在37℃下记录微生物活性，得到功率-时间曲线。计算生长速率常数（k）、抑制率（I）、最大功率输出（Pm）以及对应最大功率输出的时间（tm）等参数。结果表明，头孢他啶对大肠杆菌DH5α的抑制作用比头孢拉定更好。
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