Basić-Kes Vanja, Zavoreo Iris, Bosnar-Puretić Marijana, Ivanković Mira, Bitunjac Milan, Govori Valbona, Demarin Vida
University Department od Neurology, Reference Center for Neurovascular Disorders, Ministry of Health and Social Welfare of Republic of Croatia, Sestre milosrdnice University Hospital, Zagreb.
Acta Clin Croat. 2009 Sep;48(3):359-65.
Neuropathic pain refers to pain that originates from pathology of the nervous system. Common causes of neuropathic pain are diabetes mellitus, reactivation of herpes zoster, nerve compression or radiculopathy, alcohol, chemotherapy or abuse of some drugs, and trigeminal neuralgia. Specific symptoms of neuropathic pain are mechanical allodynia and cold hyperalgesia. Drugs to treat neuropathic pain can be divided into adjuvant analgesics (antidepressants and anticonvulsants), opioids and topical agents. The use of multiple drug therapies is common in practice. Despite considerable increase in the number of randomized placebo-controlled trials in neuropathic pain in the last few years, the medical treatment of neuropathic pain is still far from being satisfactory, with less than half of patients achieving significant benefit with any pharmacological drug.
神经病理性疼痛是指源于神经系统病变的疼痛。神经病理性疼痛的常见病因包括糖尿病、带状疱疹复发、神经受压或神经根病、酒精、化疗或某些药物滥用以及三叉神经痛。神经病理性疼痛的具体症状为机械性异常性疼痛和冷痛觉过敏。治疗神经病理性疼痛的药物可分为辅助镇痛药（抗抑郁药和抗惊厥药）、阿片类药物和局部用药。在实际应用中，联合使用多种药物治疗很常见。尽管在过去几年中，针对神经病理性疼痛的随机安慰剂对照试验数量大幅增加，但神经病理性疼痛的药物治疗仍远不能令人满意，使用任何一种药物治疗，只有不到一半的患者能获得显著疗效。
